Expressions Of HPA, MMP-9 And NF-κBp65 In Gastric Carcinoma

Objective:Malignant tumors of the digestive system account for a large proportion in the human malignant tumors and the morbidity of the stomach cancer ranks first among the malignant tumors in our country. The invasions and metastases of the malignant tumors depend on the degradation of extra cellular matrix (ECM). Heparanase (HPA) and metallopro- teinases-9 (MMP-9) are pivotal enzymes involved in the degradation of ECM and play important roles in the invasions and metastases of the malignant tumors. Nuclear factor of kappa B (NF-κB) is a kind of pleiotropic transcription factors, widely found in multiple cell types, regulating the transcriptions of multiple genes, involved in the cell proliferation, apoptosis and antiapoptosis. It has been suggested that NF-κB plays an important regulative role in the invasion and metastasis of gastric carcinoma and that its activation may be correlated with the carcinogenesis, invasion and metastasis of tumor, which is becoming a hot area of tumor research. In this study, immunohistochemistry (IHC) and flow cytometry (FCM) were used to detect the expressions of HPA, MMP-9 and NF-κBp65 in the tissues of gastric carcinoma, and the relationships between HPA, NF-κBp65, MMP-9 and other clinicopathological...