The Initial Gastrointestinal Perfusion Research In Cirrhosis By Multi-slice CT

Objective: To evaluate gastrointestinal perfusion parameters with 16 slices spiral CT and to study the changes of these parameters for liver cirrhosis with different severities.Methods: Dynamic contrast-enhanced single-location sequences CT scan of duodenum was performed in 20 control subjects and 47 liver cirrhosis patients in which 18 and 29 with compensated cirrhosis and decompensated cirrhosis, respectively, proven by clinical. Gastrointestinal perfusion parameters such as blood flow (BF) blood volume(BV) mean transit time (MTT) and permeability surface area product (PS) were calculated. The ANOVA test was applied to assess the difference of the variables among three groups. The multiple comparisons was estimated using LSD test (The BV and PS parameters were analyzed after the logarithmic transformation because of the heterogeneity of variances).Results: The BF and MTT parameters between groups were significantly altered : BF(control group 113.64±65.13 ml/100g tissue/min, compensated cirrhosis group 103.66±62.16 ml/100g tissue/min and decompensated cirrhosis group 59.26±50.36ml/100g tissue/min, P=0.004) and MTT(control group 5.78±1.95 seconds, compensated cirrhosis group 6.93±1.90 seconds and decompensated cirrhosis group 10.74±1.85 seconds, P=0.004). There were remarkable differences between decompensated cirrhosis group and any other two groups on the BF and MTT. BV and PS didn't change obviously among all groups: BV(control group 8.69±3.69 ml/100g tissue, compensated cirrhosis group 9.21±7.50 ml/100g tissue and decompensated cirrhosis group 7.16±3.58 ml/100g tissue, P=0.335) and PS(control group 18.01±1.90 ml/100g tissue/min, compensated cirrhosis group 10.32±2.84 ml/100g tissue/min and decompensated cirrhosis group 19.62±2.64 ml/100g tissue/min, P=0.056).Conclusion: Haemodynamic change of PHGE can be assessed by duodenal Multi-slice CT...