| Objectives：To explore the correlation between CT perfusion parameterof normal pancreas, the peak value (PV) and peak time (PT) of pancreas andabdominal aorta, and age and the body mass index (BMI) by the way ofapplying the technique of128-slice spiral CT perfusion imaging.Methods：1. According to the inclusive criteria of normal pancreas,60patients whoreceived contrast enhanced CT examination for the superior and the middleabdomen were randomly selected. Two patients were excluded because ofcontrast media extravasation and one was excluded due to artifacts ofbreathing motions which affected the image quality. Finally57patients wereincluded. Their height and weight was measured and recorded, and BMI wascomputed. They were grouped according to the age and BMI.2. Routine plain scanning was applied by the America GE128-slicespiral CT (LightSpeed VCT). The tube tension was120Kv, tube current was200mA, slice thickness was0.625mm×64, rotation time was0.6s, rotationspeed was39.37mm/r, matrix was512×512, pitch factor was0.984, and filterfunction was FC10.3. Pancreatic perfusion imaging extent was determined by the plainscanning. Bolus injection was done via ulnar vein by using50mliohexol(300mgI/ml), at a flow rate of5.0ml/s. The scanning parameters were 80Kv,200mA,0.625mm×64slice thickness,1s rotation time,40mm detectorcoverage,0pitch,512×512matrix, FC10filter function. The delay time was5s, interval time was1s, total time of exposure was26s, and data acquisitionlasted for52s.8-slices images were acquired by one exposure, and therewould be208-slices perfusion images finally. Routine contrast enhancedscanning would be done by50~60ml contrast media at a flow rate of3.0ml/safter perfusion imaging.4. These date of perfusion imaging were processed on the AW4.5postprocessing workstation. Applying the Body Pancreas module of perfusionanalysis software CT perfusion4to process these date. CT perfusionparameters of the region of interest of pancreas were measured and recorded.The PV and PT of abdominal aorta and pancreas were acquired, and thedifference values of both parameters were computed, too. And all values werestatistically analysed then.Results：1. Groups of age： The pancreatic perfusion values of BF, BV, PS andMTT, the PV, PT, difference value of PV, difference value of PT of pancreasand abdominal aorta in the Group aging44or below were(130.7524.83)ml/(100g min),(28.004.26)ml/100g,(17.0623.06)ml/(100g min),(13.71±2.70) s,(136.68±19.84)HU,(27.18±3.68)s,(420.48±75.15)HU,(21.53±3.36)s,(283.79±60.42)HU,(5.65±1.62)s, respectively; the values inthe Group aging between45and59were (120.1329.34)ml/(100g min),(24.23±5.62)ml/100g,(14.7112.30)ml/(100g min),(13.492.89)s,(126.9815.21)HU,(28.31±4.59)s,(433.06±59.72)HU,(21.62±3.53)s,(306.08±53.80)HU,(6.69±2.26)s, respectively; the values in the Group aging60or above were (116.3132.43)ml/(100g min),(23.614.34)ml/100g,(16.8721.94)ml/(100g min),(13.33±2.94) s,(132.04±17.22)HU,(28.14±3.96)s,(456.14±87.99)HU,(21.57±3.06)s,(324.10±75.59)HU,(6.57±2.14)s, respectively.2. Groups of BMI: The values in the Group with BMI22or below were(123.0929.40)ml/(100g min),(26.635.25)ml/100g,(14.7916.34)ml/(100g min),(14.19±3.26)s,(134.91±22.93)HU,(28.61±4.11)s,(437.47±84.73)HU,(22.26±3.21)s,(302.56±68.38)HU,(6.35±2.06)s, respectively; the values of in theGroup with BMI above22were(121.8729.06)ml/(100g min),(24.235.03)ml/100g,(16.7219.61) ml/(100g min),(13.062.38) s,(128.5512.06)HU,(27.47±4.16)s,(433.29±63.23)HU,(21.12±3.35)s,(304.74±58.99)HU,(6.35±2.12)s, respectively.3. It was found by the correlation analysis that negative correlationexisted between age and blood flow and difference value of PV (P<0.05). Andthe results also demonstrated that BMI was negatively correlated with the PVof pancreas (P<0.05). The other parameters had no correlation with age andBMI (P>0.05).Conclusion：The blood flow of pancreas and the difference value of PV of abdominalaorta and pancreas gradually declined along with the increasement of age. ThePV of normal pancreas gradually decreased as following the increasement ofBMI. The other parameters are less or not influenced by the individualfactors. Objectives：To explore the characteristics of hemodynamics for normalpancreas coexist with HBV-related liver cirrhosis by the way of applyingthe technique of128-slice spiral CT perfusion imaging.Methods：1. According to the inclusive and exclusive criteria of HBV-related livercirrhosis,30patients who received contrast enhanced CT examination for thesuperior and the middle abdomen were randomly selected and recorded asgroup of liver cirrhosis; and57patients were recordered as group of normalcontrol. All patients’height and weight was measured and recorded, and BMIwas computed.2. Routine plain scanning was applied by the America GE128-slicespiral CT. The tube tension was120Kv, tube current was200mA, rotationspeed was39.37mm/r, rotation time was0.6s, matrix was512×512, filterfunction was FC10, and pitch factor was0.984.3. Pancreatic perfusion imaging extent was determined by the plainscanning. Bolus injection was done via ulnar vein by using50mliohexol(300mgI/ml), at a flow rate of5.0ml/s. The scanning parameters were80Kv,200mA,0.625mm×64slice thickness,1s rotation time,40mm detectorcoverage,512×512matrix, FC10filter function,0pitch. The delay time was5s, interval time was1s, total time of exposure was26s, and data acquisitionlasted for52s.8-slices images were acquired by one exposure, and therewould be208-slices perfusion images finally. Routine contrast enhanced scanning would be done by50~60ml contrast media at a flow rate of3.0ml/safter perfusion imaging.4. These date of perfusion imaging were processed on the AW4.5postprocessing workstation. Applying the Body Pancreas module of perfusionanalysis software CT perfusion4to process these date. CT perfusionparameters of the region of interest of pancreas were measured and recorded.The PV and PT of abdominal aorta and pancreas were acquired, and thedifference values of both parameters were computed, too. And all values werestatistically analysed then.Results：The analysis indicated that statistically significant difference existed inthe BF, BV, MTT, PV and the difference value of PT between the group ofliver cirrhosis and group of normal control (P<0.05). The BF, BV and PV ofliver cirrhosis group were smaller than that of normal control group; and theMTT and the difference value of PT of liver cirrhosis group were longer thanthat of normal control group. And there was no statistical significance existedin other parameters between both groups (P>0.05).Conclusion：The perfusion of pancreas coexist with HBV-related liver cirrhosis wasdecreased. And this change of hemodynamics was similar as the characteristicof pancreatic microcirculatory disturbance in the early phase of acutepancreatitis. The result indicated that pancreatic microcirculatory disturbancemight be existed in the patient with HBV-related liver cirrhosis. So we shouldpay attention to a possibility which pancreatitis appeared. |
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