Study Of MSCT Perfusion Imaging Of Early Cirrhosis

Objective To explore the practical value of perfusion parameters of earlycirrhosis, as well as the variations of the blood flowing in the the left and right lobe bythe analysis of the variations of the blood flowing in hepatic perfusion with multi-slicespiral CT.Methods18cases with cirrhosis were collected in Qinghai University AffiliatedHospital from July2011to February2012,all the patients were diagnosed through theclinical history, laboratory examination and imaging examination (According to theclinical diagnosis standard of liver cirrhosis in viral hepatitis prevention and controlscheme which is set by Chinese Medical Association in2000.) There are9cases ofearly stage (male six, female three), with an average age of50.4years，9cases ofmiddle-late stage (male five, female four), with an average age of55.2years and10normal cases as control (male seven, female three), with an average age of42.8years.Perfusion CT imaging were performed in all subjects with The Philips Brillance16row helical CT, hilus hepatis as the center of scanning level, portal vein, artery inthe liver and the spleen at the same level, draw areas of interest time-density curve(TDC). ROI time-density curves were performed, the amount of hepatic arteryperfusion (HAP), portal vein perfusion (PVP), total hepatic perfusion (TLP), hepaticperfusion index (HPI)，peak enhanced(PEI),time to peak(TTP) and blood volume(BV)were calculated with deconvolution method. Data analysis:(1) SPSS statisticalsoftware package (version17.0) were performed, measurement data showed as (X±s), compares the two groups of two single factor analysis of variance, inspectionstandards α=0.05, P <0.05as statistically significant.(2)The perfusion parameterswere compared by the paired t-test to determine whether there were significantdifferences between right lobe and left lobe of liver.Results (1) Comparisons among three groups: Normal control group and liver cirrhosis of the early period of the group, Cirrhosis middle-late group all hadsignificant difference (p <0.05)in PVP, BF, HPI, TTP and BV,Liver cirrhosis earlygroup and normal control group, liver cirrhosis middle-late group had significantdifference (p <0.05)in BF, PVP HPI, TTP, BV. Normal control group and livercirrhosis, liver cirrhosis of the early group middle-late and cirrhosis early group and inthe normal control group, liver cirrhosis middle-late between groups PEI and HAP hasno significant difference (p>0.05).(2) Compare of the right hepatic lobe of earlycirrhosis group and the left lobe of liver was statistically significant (p <0.05)in HAPand HPI. The perfusion parameters (PEI, TTP, BV, BF) of the right lobe and the leftlobe of liver had a rising trend.The perfusion parameters of right liver lobe group andleft liver lobe group (PEI, TTP, BV, PVP, BF) has no statistical difference with twotwo comparison method (p>0.05).Conclusion This study determined the perfusion parameters of different groupsof liver cirrhosis and the normal control group, and found that the TTP、BV、PVP、BF、HPI and others of the early period group had obvious change and had a certainrule,which have a certain significance to clinical diagnosis of early cirrhosis. Butbecause of the less sample is not enough to get quantitative diagnosis of earlycirrhosis of the liverA large number of clinical laboratory and clinical pathologic toconfirm the conclusion; parameters of early liver cirrhosis of the right and left lobeperfusion are different, and liver HAP of left lobe is higher than right, differencebetween left lobe and the right liver is significant, indicating that the left lobe of liverhave higher artery blood supply proportion than right, plain, while the portal veinperfusion of the left and right lobe had no significant change; According the the study,we can see the chang of perfusion parameters had something to do with the severity ofthe disease,indicating the follow-up examination，observing the blood supply and liverfunctionand and to guide further treatment.