| ObjeciveAcute gouty arthritis is a common disease and stubborn disease in orthopedics. Along with the elevation of living standard and the changing of food and drink structure, the morbility of acute gouty arthritis increases year by year. In the recent years the morbility of acute gouty arthritis is about 3%o and corresponds to the cancerous incidence. Acute gouty arthritis has impacted human healthy and quality of life severely. In the treatment of this disease, the medical doctors used to apply dephlogisticate or alliviate and symptomatic treatment, but for their apparente poison and side effect and also for the recurrence of this disease after drug withdraw. So in some degree, the application of these drugs is limited. The Sihuangshuimi is manufactured and produced by the Guangdong hospital of Chines Tradictional Medicine. It has a good curative effect in the therapy of humid heat type disease. Simiaosan is an empirical formula in the treatment of acute gouty arthritis. It is aplplied to treat acute gouty arthritis frequently and got significant clinical curative effect. The research objective is to investigate the clinical curative effect about the oral administration of Simiaosan jiawei combined with the external application of Sihuangshuimi in the treatment of acute gouty arthritis and to seek for a safe and valid program for it. MethodsAll the 65 patients of acute gouty arthritis were choosen from the patients from out-patients' clinic or in-patient of the Guangdong Hospital of TCM. And all the patients consistent with the internalize standard were randomly divided into two groups. The treament group was treated by simiaosan jiawei and combined with the external apllication of Sihuanhuimi. The control groupwas treated by Qiushuixianjian. Then reference to the ((New Traditional Chinese Medicine Clinical Study Direction Principle )) made a observation table according to patients' grade of acute gouty arthritis symptoms and physical sign. After a week, all the acquired data were done statistical treatment, and carried out prior treatment and post-treatment comparision and group comparison. To evaluate the blood uric acid (BUA), the temperature (T), the lencocyte count (WBC), the joint function, the comprehensive curative effect, and side effects etc of these patients. ResultsThe therapies of two groups are equivalence. The total effective rate of treament group is 90.9%, the control group is 90.6%. After been examined by Ridit analysis (P>0. 05), the difference between two groups has not statistical significant. Comparing the symptoms and physical sign' integral of patients before treatment and post treatment, except for the BUA of control group has not statistical significant (P>0. 05) , all the other indexs have statistical significant (P<0. 01) , the results of before treatment are better than that of post treatment obviously. The comparison between two groups, except for BUA of the treament group has an advantage to the control group (P<0. 05) , the other indexs have not statistical significant between two groups (P> 0. 05) . There are no cases to appear side effect in treament group. The control group has 5 patients to show up side effect. Among them, there are 2 patients not well with their stomaches, safety rating for 3 Class, and they can keep on this research after treated according to their symptoms. Besides of it the other 3 patients appear kidney function abnormality, safety rating for 2 Class, but their kiney funtion can change to nomal level without any special treatment, and all of them can keep on this research. Cone I us i onThe effect of using sihuangshuimi combined with simiaosan jiawei to cure acute gouty arthritis is not only to improve joint fuction and cut down BUA leval obviously, but also to decline the body temperature^ decrease swelling and to relieve pain. Moreover it has no any side effect. It is a safe and effective therapeutic regiment for gout.
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