The Clinical Research To The Relativity Between Phlegm-blood Stasis Syndrome Of ACS And Inflammation Factors

Background: ACS is within the category of XinTong in TCM, of which pathogenesis is deficiency of Ben and repletion of Biao. The repletion of Biao can be described as phlegm, blood stagnation, cold and so on. Neoteric TCM doctors believe that phlegm-blood stasis is the result of development of pathogenic factors, more serious than individual phlegm or blood stagnation. On the other hand, most modern researches indicate that immune inflammation is concerned with unstable clot' s rupture and thrombus. During this process, the density of serum inflammation factors rises. Researches reveal that dyslipidemia is the base of phlegm, while abnormity of blood rheological indexes is the base of phlegm-blood stasis. However, nowadays, there are few researches about the relationship between phlegm-blood stasis syndrome of ACS and inflammation, therefore, it is necessary to study further the essential of phlegm-blood stasis syndrome of ACS.Objective: Study the essential of phlegm-blood stasis syndrome of ACS in the aspect of immune inflammation. Conclude the change principle of inflammation factors and blood-fat in different groups of ACS, and also, the difference of inflammation factors and blood-fat in the same group of different diseases(ACS and cerebral thrombosis (CT)).Method: Divide the ACS patients into two groups as phlegm-blood stasis syndrome and blood stagnation syndrome. The serous concentration of CRP, TNF-α , IL-6, sCD40L, MMP-9 and blood-fat is checked before analyzing the relationship between differentiation of syndromes in ACS and these indexes. Furthermore, group of phlegm-blood stasis syndrome in ACS is compared with the same group in cerebral thrombosis (CT), which has the similar pathogenesy, by the serous concentration of these inflammation factors, to see if any obvious difference exists.Result: Most of the inflammation factors and blood-fat indexes are higher in the phlegm-blood stasis syndrome group of ACS than the bloodstagnation syndrome group, especially IL-6, sCD40L and CRP (P<0. 05). The pertinence analyze of inflammation factors and blood-fat reveals that remarkable positive correlation exists between CRP and IL-6 (P<0.01), while distinct positive correlation exists between MMP-9 and FIB, sCD40L and CRP, sCD40L and TG, sCD40L and TC, TNF-aand IL-6 (P<0.05). In the contrast between phlegm-blood stasis syndrome group in ACS and the same group in CT, most indexes show no distinct difference (P>0.05), except TG and IL-6.Conclusion: Many factors and component elements are involved in ACS, while immune inflammation is an important one in the invasion process of phlegm-blood stasis syndrome of ACS. Phlegm-blood stasis syndrome of ACS is more serious than blood stagnation syndrome and its inflammation action is more active. Both the phlegm-blood stasis syndrome of ACS and CT have the same pathomechanism. The results offer evidences for the theory of "different syndromes in the same disease" and "the same syndrome in different diseases" .