Clinical Study Of Chuankezhi Injection Of Cure On Ⅲb-Ⅳ Non-small Cell Lung Cancer

Part I Literature Review and StudyWe studied the knowledge of Modern Medicine and Traditional Chinese Medicine(TCM) to Lung cancer .Then We discussed the basic and significance of the research.Part II Clinical StudyObjective:To obsever the therapeutic efficacy of Chuankezhi Injection in treating IIIb-IV non-small cell lung cancerMethods:62 patients with stage Illb-IV NSCLC were divided randomly into two groups.In Group A(as a treated group),32 patients were treated with Chuankezhi Injection combined with chemohterapy.In Group B(as a control group),30 patients were chemohterapy alone.The therapeutic efficancy of the two groups were evaluated after two course of treatment.Results:The Group A had a better effect in the remission of symptoms such as cough,polypnea,debility than Group B (P<0.05) there was no significant difference between Group A and Group B in the remission of symptoms such as hemoptysis,chest wall pain,fever(P>0.05 ).The complete and partial remission rate of Group A was lower than that of Group B,But no significance in statistics (P>0.05), Chuankezhi Injection could decrease the percentage of CD3~+, CD8~+in T-lymphocyte subcategory ststistically while the percentage of CD3~+, CD8~+in T-lymphocyte subcategory in Group B was not significant (P<0.05 ) . Chuankezhi Injection could increase the percentage of NKC, LBT, CD4~+/CD8~+in T-lymphocyte subcategory ststistically (P<0.05). Chuankezhi Injection could increase the percentage of CD4+, in T-lymphocyte subcategory ststistically while the percentage of CD4+, CD4+/CD8+ in T-lymphocyte subcategory in Group B was not significant (P>0.05 ) .Group A had a better effect of raising the quality of life and weight than Group B (P<0.05 ) ,The Chuankezhi Injection had no severe adverse reaction. Conclusion: The Chuankezhi Injection could alleviate the symptoms,improve the quality of life,increase the weight ,improve the immunity and stabilize the tumor in the IIIb-IV NSCLC patients. The Chuankezhi Injection could enhance the efficacy and reduce the toxicity of chemotherapy, and had a better effect of cureing the IIIb-IV NSCLC patients.