Investigation Of The Relationship Between Homocysteine And Blood Uric Acid With Hyperuricemia

Objective: It is known that Hyperuricemia and homocysteine (Hcy) are both risk factors in cardiovascular diseases. It is, however, not clear about the relationship between these two factors in the diseases. To investigate the relationship between Hyperuricemia and homocysteine, we examined the levels of plasma Hcy and blood uric acid (UA) as well as blood glucose, insulin and lipids levels in patients with hyperuricemia. We, subsequently, analyzed the relationships between the blood uric acid level and Hcy. We further explored the relationship of both Hyperuricemia and Hcy with the other traditional cardiovascular risk factors such as the glucose/insulin and lipid metabolic disorders. The aim of this study is to provide valuable information for the prevention and treatment of cardiovascular diseases.Method: 107 hyperuricemia patients (HUA) were divided into four groups. Group HUA-1 has 26 patients with sole hyperuricemia. Group HUA-2 has 29 patients with hyperuricemia and hyperlipemia. Group HUA-3 has 25 patients with hyperuricemia and diabetes mellitus. Group HUA-4 has 27 patients with hyperuricemia, hyperlipemia and diabetes mellitus. 37 normal people from the annual check-up in our hospital were chosen as the control group (CON). These 37 people have no coronary heart disease, diabetes mellitus and hypertensive disease, and their plasma blood glucose, lipids, uric acid levels are in the normal range. All people are examined for general conditions such as age, body mass index, waist-hip ratio, systolic blood pressure and diastolic blood pressure as well as biochemical variables including Hcy and uric acid levels, total cholesterol, triglyeride, high-density lipoprotein, low-density lipoprotein, fasting plasma glucose, fasting blood insulin and blood creatinine.Results: The level of Hcy in group HUA-1, HUA-3 and HUA-4 are much higher than that of the control group (P<0.01). The plasma level of Hey in group HUA-2 is notably higher than that of the control group (P <0.05). Among the four HUA groups, the level of Hcy has no significant difference (P >0.05). After controlling BMI, SBP, DBP, in the HUA group:The UA level is positively relevant to the levels of its plasma Hcy (r=0.319, P<0.01) and TG, TC, HOMAIR, FINS, CR (r=0.185-0.652, P<0.01).The UA level has negative correlation to HDL-C level ( r=-0.312, P <0.01). Hcy level is positively relevant to the levels of HOMAIR, FINS and UA.Further multivariate regression analysis revealed that HOMAIR,TG,HCY,Cr, WHR and HDL-C levels contributed to the UA levels (P<0.01)Conclusion:1. Homocysteine has correlation with hyperuricemia.2. Homocysteine and hyperuricemia become more and more severe with the progression of suger and lipid metabolic disorder.3. Reducing homocysteine and hyperuricemia maybe helpful in the prevention and treatment of cardiovascular diseases.