Pathologic Changes In The Stomach(animal) At The Site Of Silicone Gastric Banding

1. ObjectiveLaparoscopic Adjustable Gastric Banding(LAGB) is considered one of the most preferred surgical option for morbid obesity, which is effective, misinvasive, less complications and safe. More and more obese patients took LAGB for losing overweight. However, there are not many clinical cases to discuss the pathologic changes in the stomach at the site of silicone gastric banding and no animals experiments have been to do. It is hard to take biopsy in clinical cases. So animal experiment was done to observe the pathologic change in the stomach at the site of silicone gastric banding in our center.2. Materials and Methods2.1 Thirty-five rabbits, 6-month old, male, weight 2.671-3.115kg,mean weight 2.755kg. Thirty-five rabbits were randomly divided into seven groups. One was the control group and six observation groups labeled A B C D E F. There were no significantly difference among groups about weight and all rabbits were fed up with same foods and lived in the same room.2.2The animals were anesthetized by intraperitoneal injection with 10% pentobarbital sodium 10-12ml(30mg/kg). Under the processus xiphoideus, the insicion on the anterior midline is about 4-6cm to show the stomach. Cut the corpus ventriculi about 1cm in diameter and insetthe drainage into the stomach.Open the minor corpus ventriculi where is no blood vessel and drawn the silicone banding from major curvatura ventriculi to minor corpus ventriculi like LAGB, then bundle the stomach with drainage. At last, remove the drainage and suture the incision on the stomach. Labeled the rabbits.2.3 After 1 week,2 weeks, 1 month,2 months,4 months,6 months with silicone banding surgery, the band removed and took the full-thickness gastric wall biopsies.3. Results 19 cases had only serosal fibrosis at the banging site. Other 11 showed no pathologic change. There was no evidence of ischemia and evidence of penetration of the gastric wall by the band and no P53 positive cases.4. Conclusions Pathologic changes in the stomach (animal) at the site of silicone gastric banding is safe to animal. There was no apparent relationship between the changes observed and time after surgery, this study can approve LAGB is feasible and safe.