A Comparative Study In Earlier Schizophrenic Patients Treated With Aripiprazole,Quetiapine And Risperidone

Objective: 1. To compare short term (6 weeks) therapeutic effects of aripiprazole, quetiapine, risperidone in hospital patients with earlier schizophrenia. 2. To investigate the effects of the three atypical antipsychotic drugs on biological parameters( body mass, blood glucose , blood-fat, leptin and prolactin [PRL] ) in earlier schizophrenic patients. 3. To compare the effects of them on cognitive functions (visual attention, intelligence, execution function). 4. To analysis the associations between cognitive functions and clinical symptoms in patients with earlier schizophrenia 5. To explore whether the cognitive function of earlier schizophrenic patients is impaired or not.Methods: The case-control study design was used in this study and 95 schizophrenic patients were randomized into aripiprazole group (31), risperidone group(32) and quetiapine group(32) .The effects of patients in three groups was evaluated before the treatment and after six weeks with Positive and Negative syndrome Scale(PANSS). Serum level of Leptinajid prolactin were determined by enzyme linked immunosorbent assay.Bpdy mass and body height were measured. Serum level of triglyceride(TG), bloodiglucose, T —CHO, HDL —C, LDL —C were determined in automatic biochemistry analyzer at equal pace. Intelligence , execution function and visual attention were tested by Wisconsin Card Sorting Test (WCST) and Continuous Performance Tfisk(CPT).Results: ?The differences of the short term therapeutic effects of aripiprazole , quetiapine and risperidone in earlier schizophrenic patients is not statistically significant (P>0. 05). ?It seems that cognitive functions of earlier schizophrenic patients are impaired;Aripiprazole, qUetiapine, risperidone can improve different aspects of cognitive functions, ojf them, Aripiprazole can improve execution function, quetiapine can improve execution function visual attention and intelligence, risperidone can improve execution function, visual attention. ?Serum level of prolactin of earlierschizophrenic patients is higher than that of normal controls before and after itreatment;Serum level of prolactin of male patiens is higher than that of femalejpatients before treatment, while the differences of Serum level of prolactiniils not statistically significant between male patients and female patiens aftertreatment. Serum level of prolactin of male patiens treated with quetiapine andirisperidone steped up after treatment, but that of female patients changed quiet. Effects of aripiprazole on prolactin in earlier schizophrenic patients are unobvious. (DSerum level of leptin in male and female patients stepped up aftertreatment with ar ipiprazple and quetiapine. KlTects of ri sper i done on leptin in earlier schizophrenic patients are unobvious. (5) The three antipsychotic drugs also influenced blood glucose and blood fat. Serum level of glucose stepped up after treatment with quetiapine, Serum level of glucose descented after treatment with risperidone, effects of aripiprazole on blood glucose is unobvious. Serum level of triglyceride (TG) stepped up after treatment with aripiprazole, quetiapine, risperidone. Serum level of T—CHO stepped up after treatment with quetiapine and risperidone, but it changed unobvious after treatment with aripiprazole.Conclusion: the differences of effects of aripiprazole, quetiapine, risperidone on clinical symptoms in patients with schizophrenia is not statistically significant. They can all improve cognitive functions of earlier schizophrenic patients. Effects of them on biological parameters were different.