Effects Of Risperidone, Quetiapine And Aripiprazole On Glucose And Lipid Metabolism In Schizophrenic Patients

Objective: To evaluate the effects of risperidone, quetiapine and aripiprazole on the glucose and lipid metabolism of patients with schizophrenia.Methods:99 patients with schizophrenia who met Chinese Classification and Diagnostic Criteria of Mental Disorders were divided into risperidone group, quetiapine group, and aripiprazole group. The fasting glucose, 2-hour plasma glucose, fasting serum insulin, connective peptide, fasting triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein, the height, body weight, waistline and hip circumference were measured before and 6 weeks after treatment. In addition, the body mass index (BM1), waist-to-hip-ratio (WHR), insulin resistance index (IRI) were calculated. The indices were analyzed.Results:1 After treatment,the BMI,WHR levels increased significantly in risperidone, quetiapine and aripiprazole groups (P<0.05).2 After treatment, the fasting serum insulin level and IRI level increased significantly in risperidone group [(5.81±1.45) mmol/L vs. (5.4±1.44) mmol/L;(4.18±0.33) vs. (3.01±0.21), respectively] (P<0.05), but did not increase or decreased significantly in quetiapine and aripiprazole groups (P >0. 05). There were no significant changes of fasting glucose level, 2-hour plasma glucose level and connective peptide level in risperidone, quetiapine and aripiprazole groups (P>0.05). 3 After treatment, the triglyceride levels in risperidone group and quetiapine group increased significantly [(1.46±0.72) mmol/L vs. (0.87±0.37) mmol/L; (1.40±0.65) mmol/L vs. (1.24±0.70) mmol/L, respectively] (P<0.05), but did not increase or decrease significantly in aripiprazole group(P>0.05). The low density lipoprotein level in risperidone group increased significantly [(2.67±0.66) mmol/L vs. (2.87±0.66) mmol/L] (P<0.05), but did not increase or decrease significantly in quetiapine and aripiprazole groups (P>0. 05). There were no significant changes of total cholesterol level and high density lipoprotein level in risperidone, quetiapine and aripiprazole groups (P>0.05).4 There was no significant diffrence in the increase level of BMI,WHR, fasting glucose, 2-hour plasma glucose, connective peptide, total cholesterol and high density lipoprotein among risperidone, quetiapine and aripiprazole groups(P>0. 05). The increase level of risperidone on the fasting serum insulin, IRI, fasting triglyceride, low density lipoprotein was more than quetiapine, and much more than aripiprazole. Conclusion:1 Risperidone, quetiapine and aripiprazole could induce weight gain. Risperidone had some effect on insulin and IRI.There was no significant effect of quetiapine and aripiprazole on glucose metabolism. 2 Risperidone and quetiapine had some effect on triglyceride, and the increase level of risperidone was more than that of quetiapine. Risperidone had some effect on low density lipoprotein. There was no significant effect of aripiprazole on lipid metabolism.