| Objectives To investigate the change of asymmetric NG,NG-dimethyl-L-arginine(ADMA) in patients with coronary microvascular spasm angina(CMSA), and elucidate the possible mechanism of CMSA, provide experimental evidences for clinic treatment. Methods Screening 20 CMSA patients hospitalised in our hospital between Feb 2005 and July 2002, the diagnosed standards of CSMA are typical angina pectoris, positive exercise stress test and normal coronary angiography, excluded other diseases, such as hypertension, diabetes, hypertrophic cardiomyopathy et al. We selected 20 patients with more than 70% stenosis of single or multiple coronary arteries by angiography as coronary heart disease(CHD) group, and 20 nomal persons with matching age and sex as control. The levels of ADMA, NO, ET-1, SOD, MDA, blood lipid, blood glucose, blood viscosity, fibrinogen were measured respectively. Results 1. Compared with control, the levels of ADMA, ET-1 were significantly increased and the level of NO was significantly decreased in CMSA group(5.60±1.79 vs 1.01±0.05, 70.96±16.05 vs 50.58±7.52,52.8±7.59 vs 75.6±18.3, P<0.05 respectively). ADMA was positive correlated with the ratio of ET-1/NO. The levels of ADMA and ET-1 were also increased significantly in CHD group. But there was no difference between CMSA and CHD group. 2. There were statistical significance between control and CMSA group for the levels of SOD and MDA (70.3±17.8 vs 104±18.8 and 6.25±0.79 vs 4.09±0.58, P<0.05 respectively). There was no difference between CMSA and CHD group. 3. The levels of blood lipid(TC, TG, LDL, HDL-C, Lpa) in most patients of CHD were abnormal, and were higher than those in CMSA group and control group(P<0.05). There were no differences for the levels of blood glucose, blood viscosity, fibrinogen among three groups. Conclusions This study shows endothelial dysfunction in the patients with CMSA is associated with the increase of ADMA. Oxide stress may play an important role in CMSA.
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