Analysis Of The Relationship Between Coronary Microvascular Angina And Acr And Other Risk Factors Of Coronary Microvascular Angina

Objective:Detection of urinary albumin/creatinine ratio(ACR)in patients with coronary microvascular angina(MVA),Analyze its correlation with MVA;The relationship between ACR,cystatin C,cys C,Hypersensitive c-reactive protein(hs-crp)and MVA was discussed.Methods:A total of 230 patients hospitalized with chest pain in the heart department of shanxi provincial people's hospital from October 2016 to December 2017 were selected for coronary angiography.The results showed that 105 cases were not coronary atherosclerotic heart disease.In 125 cases of normal or near normal coronary angiography results was studied,the group all pedestrian athletic flat test or 24 hours dynamic electrocardiogram examination,95 cases of positive,as MVA group,30 cases of negative,as control group.According to whether the primary hypertension was combined,the MVA group was divided into simple MVA group,including 45 patients,MVA and EH group with 50 patients.Collected basic clinical data and biochemical indicators of all selected subjects,1.Analyze the changes of ACR level in each group.2.The ROC curve of the pure MVA group and the control group was drawn,and the area under the curve was calculated.The optimal critical point of MVA was discussed in ACR,cys C and hs-crp.3.Analyze the influence factors of MVA through multivariate Logistic regression.Results:1.ACR level: the ACR level of the pure MVA group was higher than that of the control group [(13.46± 4.52)mg/gCr vs(7.99± 2.41)mg/gCr,P < 0.05].The ACR level of MVA combined EH group was higher than that of the pure MVA group [(15.49±3.37)mg/gCr vs(13.46 ±4.52)mg/gCr,P < 0.05].2.The ROC curve analysis was performed on three indexes of MVA that might have predictive value: ACR,the area under the curve: 0.939,95%CI: 0.890-0.988,the best critical value: 10.05mg/gCr,sensitivity 90.5%,specificity 93.3%;Jordan index: 0.839.Cys C,the area under the curve: 0.796,95%CI: 0.697-0.896,the best critical value:0.825mg/L,sensitivity 88.4%,specificity 63.3%;Jordan index: 0.518.Hs-crp,area under the curve: 0.809,95%CI: 0.721-0.898,the best critical value: 3.690mg/L,sensitivity70.5%,specificity 86.7%;Jordan index: 0.386.3.The multi-factor Logistic regression analysis results showed that the influence factors of MVA are: ACR,hs CRP,EH,including ACR levels is one of the influence factors of MVA(OR = 1.942,95% CI: 1.332 ~ 2.832,P < 0.001),the hs-CRP(OR = 1.698,95%CI: 1.044 ~ 2.762,P < 0.05),EH(OR = 1.201,95% CI: 1.031 ~ 1.398,P < 0.05).Conclusion:ACR is used to predict the high diagnostic value of MVA.As a simple,fast and non-invasive test method,it is expected to be a predictor of MVA,providing information for early prevention of MVA.The risk factors of ACR,hs-crp and EH are MVA,which are closely related to the occurrence of MVA,and the control of risk factors can improve the prognosis.