| Objective: To investigate the dynamic changes of interleukin-6 (IL-6), interleukin-10 (IL-10), alanine transaminase(ALT), aspartate transaminas(AST), lactate dehydrogenase(LDH) malondialdehyde (MDA) superoxide dismutase( SOD) during early stage postburn,and to study the protective of salvia miltiorrhizae on the liver injury of severe scalded rats. Methods: Eighty-eight Wistar rats were randomly divided into three groups: normal control group (group A, n=8), the recovery group (group B,n=40) and the treatment group (group C,n=40).and in the two later groups a scald comprising 30 percent of the total body surface area full-thickness were performed. Rats of group B and C were resuscitated immediately with lactated Ringer's solution (120ml/kg). Additionly, rats of group C received salvia miltiorrhizae at a dose of 3ml/kg. The serum level of interleukin-6, interleukin-10, the content of hepaticenzymes (ALT, AST, LDH) ,and the activity of serum SOD and MDA were measured at 3,6,12,24,48h after burns, as well as the water content in liver. The morphologic changes were observed by light and electrical microscope. The index above were analysed to show the variations in three groups with SPSS software. Results: (1) In the fluid resuscitation groups, ALT, AST, LDH and IL-6 went up 3 hours after the burns and attained the top at 12 hours postburn; in the treatment group,the index above had the same trends as the recovery, but compared with the fluid resuscitation, ALT,AST,LDH and IL-6 were significantly lower at 3,6,12,24,48 hours after the scalding. (2) In the fluid resuscitation groups, IL-10, MDA went up 6 hours after the burns and attained the top at 24 hours postburn; the activity of SOD went down... |
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