| Objective: The intracerebral hemorrhage (ICH) is primary, not traumatic hemorrhage of brain. Its incidence, rate of mutilation and mortality are high. Body and local brain show a series of pathological changes after ICH. The edema zone occurs around hemorrhage can make neuron and its axon degenerate and apoptosis, and which make patients can not acclimatize themselves to daily living. There is anatomical isolation between nerve center and immunity system in normal circs. Blood-brain barrier (BBB) inhibits complement ingredients of plasma from going into brain. Brain tissue, such as neurons, gliacytes and endothelium cells, can synthesize a small quantity of complement, and these complement are in a steady state in normal circs. When BBB is destroyed and plasma contacts with antigen of nerve center, complement will be activated through unclassical approach of independent on alexin and destroy the intrinsic balance. Complement 3 (C3), a meeting of two kinds of activating routes and center of complement acting roles, is the maximum in all complement. That determining the content of C3 can reflect the activated function well. Complement 4 (C4) also plays an important role in the injury of complement. The international scholars focus their minds on animal experiment about the relationship between complement and edema, and rarely on patients. This study is designed to investigate the relationship between edema formation around hematoma and C3, C4, and to evaluate the effect of complement on edema formation, in order to provide valuable theories for treating and serving to clinic well. Methods: We selected every subject strictly according to the standard of diagnosis. All the subjects were divided into four groups: the normal group, the peripheral blood group, the hematoma group and the radiology group. The numerical value of leucocyte in the first three groups must be within the normal scope. The normal group included 10 cases, and all the cases were normal persons who went to do physical examination. Persons in the state of limosis were sampled peripheral blood 2~3 ml from median cubital vein after being disinfected skin. The peripheral blood group including 50 cased was divided into 1 day, 2 day, 3 day, 5 day and 7day group according to the time after onset of ICH, and each group included 10 cases. All the patients were sampled peripheral blood 2~3 ml at the specified time. The hematoma group included 35 cases. The method of dividing groups was similar to the above and each group included 7cases. We sampled every patient hematoma when carrying out micropuncture technique at the corresponding time. The first tube of hematoma was discarded and the second was conserved. The radiology group included 25 cases. The methodof dividing groups as above, each group included 7cases. We observed the relationship between the ratio of edema to hematoma and the above marker, because of the different quantity of hematoma. All the examination of CT or MRI was doing within 2 hours after ICH. All the value of C3, C4 in the peripheral blood and hematoma and the ratio of edema were expressed in the form of ( x ±s). The statistical analysis was performed with SPSS 11.0. Result: 1. In the peripheral group: The content of C3 in the 1 day group decreased when compared with that in the normal group. The trend of changes in C3 from 1 day group to 3 day group was gradually increased. The value of C3 in 5 day group was lower than that in 3 day group, while that in 7 day group was more lower. There was a peak in the curve graph of the 3th day after ICH. The trend of changes in C4 was similar to that of C3, and also showed a peak in the curve graph of the 3th day. 2. In the hematoma group: In the 1 day group, there was no significant difference in the content of C3 between that in the hematoma and that in the peripheral blood, so was C4. The content of C3 and C4 in the hematoma both reached the peak in the 3 day group. The value in the curve graph decreased gradually with the time progressed, and on the 7th day reached the level of the 1 day. 3. In th...
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