Study On The Expression Of TM In Renal Pelvic Transitional Cell Carcinoma And It's Clinical Significance

Objective To study the expression of TM (thrombomodulin) in human renal pelvic transitional cell carcinoma by the means of immunohistochemistry technic , and compare it with that in human renal cell carcinoma and evaluate whether TM can be a tumor marker that can differential diagnose renal pelvic transitional carcinoma from renal cell carcinoma , and provid a theory evidence for different therapy of two kinds of renal carcinoma . In addition , to study the relation between TM and the procession of stages and classification in transitional cell carcinoma, and provid theory for operation treatment, post therapy of operation and prognosis .Material & methods All the speciments were collected from department of pathology of The Affiliated Hospital of Medical college , Qingdao University . Our study involved renal pelvic transitional cell carcinoma (40 cases) , renal cell carcinoma (20 cases) in different stages and classification and involved speciments of normal renal tissue (10 cases) . Expression of TM were mesured by means of SP immunohistochemistry in all the speciments by using mouse anti-human TM monoclonal antibody , and the different expression in renal pelvic transitional cell carcinoma and renal cell carcinoma tissue were observed and in the meaning , different expression in renal pelvic transitional cell carcinoma in different stages and classification were observed . The results were analysised statistically .Results In 40 cases of renal transitional cell carcinoma , TM positive cases were 37 and total TM positive rates was 92.5% , The means of TM positive cell rates , which the cells with TM positive expression were compared with all carcinoma cells ,were 67.2±4.6% . In 20 cases of renal cell carcinoma , TM positive cases was 1 and total TM positive rates is 5% , and there were significant difference between renal transitional cell carcinoma group and renal cell carcinoma group, P<0.01 . There was no TM expressionin in normal renal issues . The TM positive cell rates decreased with the procession of stages and classification in transitional cell carcinoma . In addition ,there were 8 cases that occurred bladder carcinoma in 40 cases of renal...