The Pharmaceutical Study Research Of Fufangshenbeizhike Granules

The pharmaceutical study research of Fufangshenbeizhike granulesFufangshenbeizhike granules made of two or more ingredients join shellfish relieve a cough particle to underthe guidance of pharmacology theory of Chinese medicine , pass modern study of pharmacy, in guaranteeing its original and powerful principle , change powder into a kind of pure traditional Chinese medicine preparation of the particle pharmaceutical. Its prescription is made up by eight flavor traditional Chinese medicine , such as Taizishen , Mahuang , Zhebeimu , Tianhuafen ,Binlang,Baiji .Jiegen , Gancao ,etc, benefit is raised angrily overcastly, the efficiency of ventilating the lung and reducing phlegm and relieving a cough.This experiment is on the basis of the thing that the side solves and crude drags chemistry component is analysed, adopt the HPLC , TLC to carry on the preparation craft of the preparation and research of the quality level, main content and result are as follows:1: Determine the content to some crude drags with controlling index composition of every experiment, make it accord with regulation of 2000 editions (Chinese pharmacopoeia ).2: Have amalgamated and prepared technology research to Mahuang , Zhebeimu , Binlang. Regard hydrochloric acid of Mahuang as the index, adopt HPLC to determine the content of the hydrochloric acid of Mahuang , whether through is it test excellent to elect the best technology to hand in. Fetching the original crude drags sliced medicinal herbs, add 60% of the ethanol of quantity of 10 times, the backset current is drawn three times, the preparation technology of 105min is the best each time.3: To theGancao, Taizishen,Jiegen, Baiji,Tianhuafen the five flavours crude drags of root of Chinese trichosanthes have amalgamated and prepared technology research . Regard sour form ammonium salt of Gancao as the index of investigating, adopt the HPLC to determine the content of the sour form ammonium salt of Gancao, whether through is it test excellent to elect the best craft to hand in. The original crude drags add quantity of 10 times water, soak 20min , fry and boil 3 times, 2h each time; Withdraw water liquid concentrate to crude drags 1.5 of quantity , alcohol sink to 60% , quiet to put preparation of 18h technology best.4: Join to Fufangshenbeizhike granules quality control method go on research, have set up particle pharmaceutical quality level of the finished product. Determine you medicine effective composition in the Chinese ephedra with HPLC (regard content that the hydrochloric acid of Mahuang are counted ) as finished product index that ration control. Law join to Taizishen, Zhebeimu , Binlang , Gancao four flavor medicine is it determine the nature differentiation to go on with TLC, the spot clarity of the chromatogram , characteristic are strong, the reappearing is good , negative and noiseless. The method learns to show in result of study: The stability , precision , rate of recovery of this method accord with the quantitative analysis request, have offered the reliable experiment basis for inherent quality control of preparation.