The Pharmaceutical Study And Pharmacodynamics Research Of Yinxian Tongfeibao Granules

Yinxiantongfeibao granules consist of Herba Ardisiae Japonicae Folium Ginkgo, Herba Epimedii, Radix astragali, Pericarpium citri reticulatae, Fructus schisandrae chinensis Radix polygoni multiflori preparata Rhizoma paridis Rhizoma chuanxiong. Radix Angelicae sisensis. It has a good effect treating Chronic Bronchitis according to clinical experimentation for many years .The effective rate is 93%. The TCM formula is better combining the theory of TCM and the modern research and clinical experience into one.On the premise of reliable effect in clinic , It's pharmaceutics and pharmacology were systematic studied so that setting up the foundation of the preparation standardization and the new medicine's report to higher body.The first in this study,extrative condition were researched by orthogonl design and the best preparation process were determined. In quality standards studies,the study on TLC identification method for Pericarpium citri reticulatae , Radix astragali , Fructus schisandrae chinensis, Herba Epimedii, Folium Ginkgo was carried out.Then we established the content determination method of Herba Ardisiae Japonicae.Determination the content of Bergenin and the content-limited by HPLC.We also studied the preliminary stability about three types of Yinxiantongfeibao granules by constant temperature acceleration tests(40℃ ,75%).In medical effects,the lowering effect was researched to Chronic Bronchitis of animal made model,in this study ,the effect to Antitussive , De-sputum and Anti-asthma was determined.In acute toxic test,the maximun tolerance dose was also determined.The experimental results have shown that the TLC spots of Pericarpium citri reticulatae, Radix astragali Fructus schisandrae chinensis, Herba Epimedii and Folium Ginkgo were very clear in the prepartion.and had repeatability.The content Bergenin is not lower than 30mg/dai.the stabilities, sensitives, recoveries accord to the demands of qualitative analyses.These method can be used as a quality content method.The preliminary stability result indicated that characters , indentification, test, contentdetermination unchanged in three month.it showed that the quality of Yinxiantongfeibao granules is stabilized.The pharmacological results have proved that this preparation has a better functions to threat Chronic Bronchitis and Obstructive Emphysema. And the acute toxic test results have proved that Yinxiantongfeibao granules is low toxicity,and take it is safety and effective.