Clinical Analysis Of 287 Cases With Henoch-Sch(?)nlein Purpura In Children

Objective : To study the clinical characteristics of Henoch-Schonlein Purpura (HSP). Methods: The 287 cases with HSP were retrospectively studied and patterns of onset, clinical manifestations and correlated factors of renal damage were analyzed. Result: (1) The age of onset of all the 287 children with HSP were over two years and the mean age was (8. 75±3. 09) years. 52.96% of the patients revealed evident predisposing factors, mainly respiratory infection. (2) All the patients had typical purpura. The distribution of rash in the lower extremities, buttock and upper extremities was 100%, 40. 42% and 17.78%, respectively. Totally 102 cases (35.54%) developed HSP nephritis, and the ratio of boys and girls was 1. 49:1 ( P<0. 01). The recurrent of skin purpura was 55.88%(57/102) and 23.78%(44/185) for the patients with renal damage or not, respectively ( P<0.001 ) . The patients with purpura and gastrointestinal tract symptoms presented more renal damage than those with purpura only ( P<0. 005) . (3)Platelet count, Erythrocyte sedimentation rate (ESR) and level of fibrinogen (FIB) increased in 46.69%, 29.87% and 15.74% of the cases, respectively. Conclusion : (1) The most important inducing factor of HSP was infection. (2) Boys had more often renal damagethan girls. Those with recurrent skin purpura or obvious gastrointestinal symptoms tended to have renal damage. (3) The patients were in the hypercoagulatory state, and early anticoagulation therapy was necessary.