Determination And Clinical Significance Of VEGF Level In Children With Henoch-Schonlein Purpura

Objective: To investigate the changes of plasma vascular endothelial growth factor (VEGF) and its role in children with Henoch-Schonlein Purpura (HSP) .Methods: Plasma VEGF were measured by ELISA in 56 children with HSP and 38 healthy controls. The children with HSP were measured in acute period and inremission stage.Acute phase were devided into 4 groups:one was with gastrointestinal symptoms and another without gastrointestinal symptoms; the others were with renal function impairment and without.Results: Plasma VEGF levels in children with HSP in acute phase were significiantly higher than those in remission phase and normal controls,the difference was dramatic (q= 14.67,5.46,14.50,p<0.01﹚;In acute phase,the VEGF level in patients with renal function impairment was 229.83±74.25 ng/L, and that without was 194.82±138.97ng/L,showing no marked difference between the two groups(t=0.608,p>0.05﹚.For those with gastrointestinal symptoms in acute phase,the VEGF level was remarkedly higner than those without gastrointestinal symptoms,the difference was remarkable(t=2.129,p<0.05﹚.Conclusion: The plasma level of VEGF increases markedly in acute phase of HSP,indicating that VEGF is involved in pathogenesis of HSP.VEGF may have a close relationship with the damage of gastrointestinal system in HSP.