| The alloys used in PFM restorations, especially the Ni-Cralloy may cause the darkening of the gingiva and affect theaesthetics. Many researches have been conducted to evaluate theeffects of different alloys on the gingival tissue. The quality andquantity of gingival fluid is a critical index to evaluate the health ofthe gingiva. It has been reported that some alloy can causegingivitis. Many inflammation mediator and regulator have beendetected in recent years, and it is well known that IL-1β plays avery important role among these. IL-1β is one of cytokines whichhas many bioactivities. IL-1 is mainly synthesized and excreted bymonocyte and macrophage when the stimulator exits, such asmicroorganism, immune complex, cytokines. IL-1 can be classifiedinto IL-1α and IL-1β, which has similar bioactivities and theirtarget cell distribute all over. The main bioactivities that it hasrelationship with the disruptionof periodontal tissue includestimulating the production of T/B lymphocyte, producing theimmune response, inducing the inflammation of host andpromoting the absorbance of bone and cartilage. The purpose of this study is to investigate the effects of PFMcrowns on the local gingival fluid and expression of IL-1 to test thehypothesis that the Ni-Cr alloy is more likely to cause the gingivitis. 39The inner crowns are made of different alloys and have not specialmarginal treatment. All the patients are divided into 4 groups, control, platino,medical alloy containing titanium and nichrome group. Thegingival sulcus fluid were collected, the volume of and IL-1β ofwhich were detected. The results show that the quantity of gingival fluid ofexperimental groups and control group has not statisticaldifferences. As to the expression of IL-1 in the gingival fluid, Ni-Cralloy is most likely to cause gingivitis, and Gold alloy has the leastinfluence, while Tiltie alloy is the medium. This result of this studycan be a useful reference of the clinicians.
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