The Value Of P27～(kip1) And Ki-67 In Psoriatic Lesions

Objective to investgate the expression of p27kip1 and ki-67 in skin in patients with psoriasis and their significence in the development of psoriatic lesions.Methods 48 patients with psoriasis vulgaris were studied, 28 cases in progressive stage and 20 cases in static stage. 30 normal persons were chosed as controls, immunohistochemistry method was used to study the expression of p27kip1 and ki-67.Results (1) The expression of p27kip1 was significantly lower in lesions with psoriasis than that in the normal controls(p<0. 001) ;The level of p27kip1 decreased in static lesions in comparison with the normal controls(p<0. 05) ;The level of p27kip1 decreased significantly in progressive lesions in comparison with the normal controls(p<0.001); but there was no significant difference in lesional skin between progressive stage and static stage (p>0. 05). (2) The expression of ki-67: there was a significant increase of ki-67 in lesions with psoriasis in comparison with those of the normal controls(p<0.001);The level of ki-67 increased in static lesions in comparison with the normal controls(p<0. 01);The level of ki-67 increased significantly in progressive lesions in comparison with the normal controls(p<0. 001); and expression of ki-67 was significantly higher inlesions of progressive stage than those in static stage (p<0. 001). (3) There was no correlation between p27klpl and ki-67 in psoriatic lesions. (r=0. 08).Conclusion (1) The down-regulated of p27klpl is likely to relate to overproliferation of keratinocytes in psoriatic lesions. (2) Expression of ki-67 was significantly higher in psoriatic lesions than that in the controls, it was also significantly higher in progressive lesions than that in static lesions, ki-67 is a factor in evaluating hyperplasia of keratinocytes in psoriasis.(3) There was no correlation between p27klpl and ki-67 in psoriatic lesions.