Study Of Mechanism Of Invasion And Metastasis In Endometrioid Endometrial Carcinoma

Objective To study that survivin gene play an important role in invasion and metastasis of endometrioid endometrial carcinoma.Methods Reverse transcription polymerase chain reaction,western blot analysis were employed to reveal mRNA and their protein expression of survivin in cancer tissue and normal endometrium of 50 cases.Results Mean levels of survivin mRNA expression were significantly increased in tumor tissues compared with normal endometrium (T=11.376 ,p<0.005); .there are significantly difference in survivin mRNA expression between superficial myometrial invasion and deep myometrial invasion or lymph node metastasis (P< 0.05 ); significantly difference between lymph node metastasis and deep myometrial invasion(P< 0.05) . Mean levels of survivin mRNA expression were significantly increased in G3 compared with Gl ,G2 (P< 0.005 ) Mean levels of survivin protein expression were significantly increased in tumor tissues compared with normal endometrium(T=20.346 ,p<0.005 ); there are significantly difference in survivin protein expression between superficial myometrial invasion and deep myometrial invasion or lymph node metastasis (P< 0.05); there was significantly difference between lymph node metastasis and cervical invasion (P< 0.05 ) ; no difference was found among other groups (P>0.05) .Conclusion There is correlation between survivin overexpression and endometrial carcinogenesis or invasion or metastasis.