Roles Of CD₄₅RO, CD₂₀ And Local IgE In The Pathogenesis Of Vocal Fold Polyps

Objective To investigate the roles of CD45RO,CD20 and local IgE in the pathogenesis of vocal fold polyps.Methods Thirty cases of vocal fold polyps and ten cases of normal vocal folds were used in present study by immunohistochemical method to detect CD45RO, CD20 and IgE cells.A mean numbers of postive cells per high power field (10×40) were counted. All data were analyzed with t-test and correl-test by Spss10.0 software.Results The number of CD45RO+ cells,CD20+ cells and local IgE cells in vocal fold polyps was significantly more than in normal vocal folds (P<0.001). The expression of CD45RO+ cells,CD20+ cells and local IgE+ cells in vocal fold polyps was no connection relations. The expression of CD45RO+ cells,CD20+ cells and local IgE cells between male and female vocal fold polyps was no significant (P>0.05) .Conclusion There were active cellular immunity and humoral immunity in vocal fold polyps.Local allergy may play a role in the pathogenesis of vocal fold polyps.