Studies Of The Alteration Of EGG And Gastrointestinal Hormones And The Curative Effects Of Chinese Herb Medicine On Spleen-Qi Deficiency And MODS After Abdominal Surgery

Objective: To observe the changes of EGG and four kinds of plasma gastrointestinal hormones in Spleen-Qi Deficiency(SQD) and try to explore the relationship among them. Meanwhile, to observe the role of XiangSha LiuJunZi decoction and some western medicine in the treatment of SQD, the changes of EGG and gastrointestinal hormones in SQD. Method: Fifty three cases of SQD were elected and their EGG and the levels of plasma gastrin( Gas), motilin (MIL), somatostatin (SS) and vasoactive intestinal peptide(VIP) were measured. The thirty four cases were divided into two groups and were chosen for treatment with XiangSha LiuJunZi decoction or some western medicine, of which cisapride is in chief. The efficacy of treatment, changes of EGG and the content of plasma gastrointestinal hormones were also observed after treatment. Result: The EGG of SQD was disordered, which was characterized by decreased postprandial dominant frequency in normal range(N%) and dominant power(DP), increased postprandial percent of bradygastria(B%).The levels of Gas and MTL were lower than the normal controls and the levels of SS and VIP were higher. After being treated, the symptoms were efficiently relieved, postprandial N% and the levels of MTL increased and the levels of SS and VIP decreased. There was an increasing tendency in the level of Gas but there was not significance in statistics(P>0. 05). The efficacy was not difference between the two therapies. There was a negative correlation between the level of plasmaSS and Gas, DF, N% of EGG respectively. There was a positive correlation between the level of SS and B% of EGG. Conclusion: In SQD, the EGG was disordered, which is characterized by decreased postprandial N% and power, increased postprandial B%, and the levels of plasma Gas and MTL were decreased and the levels of plasma SS and VIP increased. The reason of EGG alteration is perhaps associated with the changes of levels of plasma SS and Gas, especially the SS. The reason of the alterated plasma level of MTL and VIP in SQD need further study. The two therapies have certain effect in treatment of the disease.