Nerve Growth Factor, Nerve Growth Factor Receptor, Epidermal Growth Factor, Epidermal Growth Factor Receptor, Tumor Necrosis Alpha And Psoriasis

Nerve growth factor, Nerve growth factor receptor,EpidermaI growth factor, EpidermaI growth factorreceptor, Tumor necrosis factor alpha and PsoriasisObjective: To exp1ore the relationship between nerve growth factor(NGF), nerve growth factor receptor (NGFR), epidermal growth factor(EGF), epidermal growth factor receptor (EGFR), tumor necrosis factoralpha (TNF- Q ) and the onset and developing of psoriasis by observingthe expressing of these growth factors and their receptors in skin.Methods: Skin biopsies derived from 15 specimens of lesional psoriaticskin, non-lesionaI psoriasis skin and 15 specimens of normal skin fromnormal donors. The expression of these growth factors and theirreceptors in lesional psoriatic skin, non-lesional psoriasis skin andnormal control skin was investigated with the HistostainTM-SPimmunohistochemistry (SP). The outcome was demonstrated bysemi-quantitative. Results: In comparison to the normal skin andnon-lesional psoriasis skin, All the expressing of the nerve growth factor,nerve growth factor receptor, epidermal growth factor, epidermal growthfactor receptor, tumor necrosis in lesional psoriatic skin were increasedsignificantly. Conclusion: 1. That NGF and its receptors highlyexpressed in the basal layer and upper epidermal layers in psoriasissuggests that more amount of NGF production has been stimulated bykeratinocytes proliferation and chronic dermatitis as well as the menta1factor in psoriasis. Increased NGF also facilitates keratinocytesproliferation. This manifests that the mental factor also play animportant role in the pathomechanisms of the psoriatic and indicates that.....psoriasis is a neurogenic inflammation. NGF and its low affinityreceptor p75 possibly involved in the pathomechanisms associated withthe development of the psoriatic lesion. NGF can induce two importantchemokines, interleukin-8 and RANTES, which are known to beupregulated in the keratinocytes of various inflammatory conditions.NGF significantly increased RANTES production by the keratinocytes inpsoriasis. 2. EGF and EGFR are overexpressed in the melnbran andplasam in the basal and parabasal layers, and there is obviouslydeposition in granular layer. These demonstrate that the Epidermalgrowth factor family members and its receptor (EGF/EGFR) system areinvolved in the growth of psoriatic lesional keratinocytes (PLKs). EGFand EGFR expressed in stratum spinosum and stratum corneum indicatethat EGF receptors may be, in part, responsible for thehyperproliferative state of the epidermis. This altered process of EGFreceptor production may be involved in the onset of psoriasis vulgaris.And also indicate there is disequilibrium between EGF and EGFR. Thebinding of EGFR to EGF family members maintains the epidermalhyperpro liferation, abnormal keratinization and inflammation. 3. Theexpression of TNF-alpha increased significantly in the intercellularspaces and on the membran in lesional psoriatic keratinocytes. ThisresuIts manifest that psoriasis is an inflammatory disease and that theskin inflammation triggered by TNF-alpha is a very important reason incausing and maintaining psoriatic skin pathologic feature. The continuedproducing of TNF-alpha makes the continued producing of othercytokines and regulates these cytokines, thus causes continuedproliferation and differentiation of keratinocytes. TNF-aIpha in lesionalpsoriatic skin are keratinocytes, T cells, neutrophils in psoriatic lesionskin.