Clinical Study Of Treating Peripheral Menopause Syndrome (PMS) With The Decoction Of Yi-Shen-Kun-Ning

Objective: To observe the curative effect of treating peripheral menopause syndrome (PMS) with trie decoction of Yi-Shen-Kun-Ning and explore the mechanism of it. Method: To observe the clinical symptoms' improvement of 45 cases with PMS after treatment and changes of catecholamine in urine, some serum hormone such as FSH, LH, E2, some trace elements including Zn, Cu, Fe, CD subgroup of peripheral blood T lymphocytes , AKP and Ca/Cr in urine. Results: The clinical symptoms are significantly improved and the totally effective rate is 95.6%. Kupperman evaluation before treatment is significantly different from that after treatment.(P<0.01). There is a low level of E2 and a high level of FSH and LH, but there are significant changes after treatment (P<.01, P<.05). The CD subgroup of peripheral blood T lymphocytes and some trace elements such as Zn, Cux Fe is significantly increased(P<0.01,P<0.05), the catecholamine and Ca/Cr in urine is significantly decreased (P<0.01). Conclusions: The decoction of Yi-Shen-Kun-Ning can better improve the clinical symptoms of PMS. And the mechanism might be related to improve the function of hypothalamus-pituitary-ovary axis, regulating nerve system and increasing the trace elements. Besides, the decoction of Yi-Shen-Kun-Ning can regulate the function of immune system.