Clinical Study Of Xin-Chang Ning Mixture On Treating Irritable Bowel Syndrome

Objective: To investigate the therapeutic effect of Heart-calming and gut-smoothing method in the treatment of Irritable Bowel Syndrome (IBS). Method: 80 cases of IBS (according to Rome-11 criteria) were divided into two groups randomly. The treatment group (including 28 D-D3S and 15 C-IBS cases) were treated with Xin-Chang Ning Mixture orally, and among the control group 33 D-IBS cases were treated with Berberin Tannate,14 C-IBS with Cisapride orally. The treatment course was 15 days. The clinical effect was evaluated by the change of main symptoms' score after the course. Results: The therapeutic effect of treatment group is obviously superior to control group in treating abdominal pain and diarrhea(pO.01),but inferior (p<0.05) in treating constipation while in terms of the total effect for C-IBS patients the two groups have no significant difference. In the two groups the total effective rates were 95.35% (41/43) and 56.76%(21/37) respectively, and the difference was significant in statistics(p<0.01). The results also show that Xin-Chang Ning Mixture group has more therapeutic effect than control group in improving sleep disturbances (p<0.01). Conclusion: Heart-calming and gut-smoothing method is effective for IBS especially for D-IBS. The mechanism maybe to modulate the disturbances of "brain-gut communication", and so make the function of the bowel from disorder come to order,the abnormal interaction between brain and gut come to end.