Clinical Study On Variation Level Of Angitasis Factoro In Limb Vascular Disease Of Diabetes

The vascular disease in the limbs may result from diabetes mellitus.There has been increasing appreciation of the morbility associated with limb vascular disease in diabetes(LVDD),including recent a markedly decreased quality and average span of life.Several decades studies indicate that its pathogenesis is associated with the vaso-active substance secreted by vascular endothelial cell .This article aims at investigation of variation level of the angiotasis factor,such as endotheliotoxin-l(ET-l), nitrous oxide(NO) -. thromboxane B2(TXB2) 6-keto-prostaglandin FI . (6-keto-PGFi.) in the patient with LVDD by clinical observation. 60 patients with LVDD were selected as the test group(Among them 30 patients were attributed to the symdrome of blood stasis,and the others were attributed to pathogenic dampness-heat attacking the lower limb according to the syndrome differentiation in TCM).Patients with non-vascular complication in diabetes or with arteriosclerosis obliterans(ASO),and health adults,20 persons respectively,were observed as the control group.The results show that the levels of plasma ET-K TXB2> T/Pand serum NO in patients with diabetes were higher than normal,but the plasma 6-keto-PGFi ?were lower than normal.Patients with LVDD attributed to the sydrome of blood stagnation had higher plasma level on ET-K TXB2 -. T/P and serum NO but a decreased level on 6-keto-PGFi ?when compared with diabetes control group.Patient with LVDD attributed to the pathogenic dampness-heat attacking the lower limb had a higher level on ET-1 , TXB2 T/P and a decreased level on NO and 6-keto-PGFi a when compared with diabetes group.It is suggest that the angiotasis factor play an important role in the pathogenesis of the LVDD.