| ABSTRACT Objective: The alterative expression of P53 protein and IGF-r in pancreatic carcinoma tissues may offer some important information concerning the etio-pathogenesis of this disease and accumulating objective data of molecular pathology for diagnosis and therapy practice. Methods: Immunohistochemical detection of P53 protein, IGF-r in 39 specimens of patients with pancreatic carcinoma and 19 specimens with chronic pancreatitis the positive frequency of these tissues were analysed. Results: The positive frequency of P53 protein and IGF-r immunoreactivity was 61.54%(24/39) and 66.67%(26/39) in tumor tissues, it indicated significantly higher than that in chronic pancreatitis tissues(5.26% and 36.84%) (P＜0.05); In cancer tissues, the positive frequency of P53 and IGF-r was 20%(3/15) and 33.33%(5/15)in high grading group, which showed significant lower than in mid-low grading group (87% and 79.3%)(P＜0.05).Conclusion: 1.P53 mutation and IGF-r overexpression may have critical effect on pancreatic carcinoma; 2.Overexpression of P53 and IGF-r was associated with pathohistologic grading of pancreatic carcinoma; 3. Detection of these biomolecle may offer the useful index for diagnosis and therapy of pancreatic benign and malignant lesions.
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