The Detection Of Pancreatic Carcinoma P53 Protein, Clinical Application Of Ca242 In Marker Of Abnormal Changes In Value

Objective: Detection of P53, CA242 proteins in pancreatic carcinoma tissues may offer some important information for early diagnosis, therapy and prognosis of this disease. Methods: P53, CA242 protein in tumor and 19 non-tumor tissues of patients with pancreatic cancer and benign lesions of pancreas were detected by immunohistochemistrical method(LSAB). Results: 1. The positive immunostaining of P53 protein and CA242 were identified in cellular mucleus or cytoplasms in most tumor tissues, the density distributions of the positive cell in Tumor or inflammatory tissues was uneven. 2.The positive frequency of P53, CA242 was 61.5%(24/39), 64.1%(25/39) in cancer tissues, and revealed more high than in non-tumor tissues 5.26%(1/19), 21.05%(4/19)(P<0.001~0.05) respectively; 3.High frequency in mid-high grading tumor (92~81%, 92.3~90.3%) than in low grading tumor tissues 20%, 13.3%(P<0.05) was also found. Conclusions: 1. Overexpression of P53, CA242 protein with high frequency may involve the pancreatic carcinogenesis; and also reflected the tumor grading; 2.Detection of these tumor-associated molecules may offer important index for early diagnosis, therapy and prognosis in human pancreatic carcinomas.