An Experiment Study Of Gukang In Prevention Of Osteoporosis On Ovariectomized Female Rats

An experim.nt 8tudy of Guk.ng in prev.ntlon ofosteo,oro8is on ov.ri.ctomiz.d f.mtI. r.t8ABSTRACTPrimary ostcoporosis is characterized by reduction of bonemineral density (BMD) and microstructure degeneration of tbebone tissue. It is a general bone disease that the bone-fragility isincrcasing and a consequent increase in fracture risk. PrimaryosteoporoseS weTe dividcd iato postmenoPausal osteoPOtosis andsenile o8teoporosis. Osteoporosis is reIated to heredity. endocrine,nutrition. life-style etc al.Osteoporosis is one of the tenth disease in common disease.Postmenopeusal osteoporosis is a difficult problem in medicinalfieId. ERT is often used to treat and prevent tbe disease .Themethod has great sidc-effect and the period of treatment is toolong, aIso the curative effect is not sure. Some medicine such asCT,Diphosphatc. Ipriflavone, Active VtminD3 produce a goodcurative effect and have littIe side-effect wben they were used totreat the disease. They wcre unacceptable by the patients becauseof thc high pricc, the paticnts can not afford to usc such medicinefor long time. Tbe drugs that they can prevent and cure OP is oncof the fOcal points, the drugs should be little side-effect andproduce a good and gencral curative effect, the reasonable price ofthe drug is also very important, the Traditional Chillese Medicinehas such superiority.At present OP fall into the category of "Guwei"(Gu mcans boneand Wei means fading). The main pathogeneses of OP were the4kidney vacuity,the spIeen vacuity and the bIood stasis. Ourteacher professor Qillgsi Liu considered that OP is a such diseasethat it have many reasons and effects,much vacuity and muchstasis. He put fOrward the therapeutic and prevention principlesfor OP, the principles are as followingst invigorating the kidneyand strengthening bone, supplemcnting the spleen and boost Qi,quickening blood and freeing the connecting vessel. The principlesreflect the recongnization of T.C.M. fOr OP,"Gukang" was workedout by professor Liu on the base of the therapeutic, Gukang accordwith the therapeutic principIe of OP The clinic effect of Gukangwas tested and verificd by many clinic practice and animalexperiments. The principle give theoretical basis to the medicineresearch, it can also estabIish a fOundation to develop and applythe medicine fOr OP in mass.l2month-oId unmixed SD rats were uscd to the study on theprevention and therapy of OP Scientific design, strict operation,rigorous index determination make the experiment succcss. TheresuIt suggest the OP postmenopausaI animaI modeI created by theexcision of ovary on the rats is successful, the conclusion is drewfrom thc compare of control group and model group. "Gukang"can incrcase BMD, improve the biomechanics property of bone,increase the contents of E2' BGP in the serum, decrease thecontents of IL-6 in the serum of the rats. It can restrain thcabsorption of bone and promote the fOrmation of the bone, itreflect the uterus. lt can supplementing the kidney and strengththe bone. The possible mechanisms just like this; hormone-likecffect. the improvement of the level of l,25(OH)2D3. promoteproliferation and differentiation of the osteobIast; restrainpro1iferation and differentiation of the osteoclast; improve the5absorption of Ca++ in the intestine, regulatc the balance of themicroelement in the internal surroundings and promote theformation of bone. AIter molecul structure of ostcoporosis modelanimal bone matrix, augment machinemechanics behavior.The prevention of OP by "Gukang" is based on whole therapy,it can rcgulate many systems and many organs to rcstore the bodyfunction to prevent OP.