The Experimental Study Of The Effect Of Chinese Herb GuKang On Cure The Fracture Resulted By Postmenopausal Osteoporosis(PMOP)

The experimenta1 study of the effect of Chineseherb GuKang on cure the fracture resu1ted bypQStmenopausal osteoporosis (PM0P)arna0steoporosis(0P) is a systemic skeleta1 disease characterized by1ow bone mass and microax.chitectura1 deterioration of bone tissue (thebone trabecu1a of the spongiobone attenuate and broken and its quantity'decreased, the corticobone becare porosis and thin), with a conseqUentincrease in bone frngi1ity and susceptibility to frature r1sk. Fractureresulted by 0P 1s the rmin cause of the high death rate and the decreased1ive qllality of the patient suffered from 0P o It increased the burdenof the fami1y and society, with the PYocess of the wor1d human ngingcome on, more and more peOPle will suffer from this:Thus hOW to preventand cure 0P, has became a critical research task of the who1e wor1d oThe nain c1inica1 smptoms of 0P ax.e osteoa1gia \ deformation ofthe body and fracture o It be1ongs to "GooI" of TIC, and kidney deficiencyis the main P8tho1ogy o Chinese herbs deyelOPed under the theory treatthe 0P from kidney have some effects on 0P on clinic, but it is notsatisfactory o Through ten years studying and sumning up experience,my arester LIUQINGSI suggested that the treatment PI'incip1e of 0P ax.estrengthen kidney aJnd bone. invigorating sp1een QI and activating bloodcirculation to dissipate blood stdisis o He selected ten Chinese herbsto compose GuKang, which has satisfied effects on 0P in a c1inica1observation on ten thousands case of 0P oThrough document review and PYevious experiment study on GuKang,we tale an anime1 mode1 with postmenoP8usal 0P cOmp1icated by anincOfnP1ete fracture in the 1eft upper tibia of rat by reamving ovaries,in this experiment, in order to study the treatment effect of GuKangon fracture resu1ted by PM0 and eXPlore its mechanism, we dividedaniam1s into groups random1y and observed the effect of GuKang onfracture resu1ted by P0MP comPgred with the positive drug at the sare5time, using DEXA, Serum E2. a. TNF, exanination of bone tissue andbiomechanic of bone as indexes, The resu1t indicated that: 1. The anima1mode1 was made successfu11y o 2.GuKang can increase BMD obviously(include corticobone):it can inyove biomechanic of bone effective1ywhich is better than Ni1estrio1, it a1so can increase serum E2. CT andlow serum TNF which shows GuKag can cut doWn the so1ve of bone andpromote synthesis of bone, with the examination of bone tissue, we findGuKang can treat PM0P and PI'omote the hea1ing of fracture resulted byH at the same time o 3. GuKang can increase the seram E2. CT and decreasethe seruJn TNF obvious1y of the postmenopausa1 anima1 mode1, whichindicates GuKang has hormne--1ike effect, and is better than Ni1estrio1on supPI'essing bone absorption o It a1so shOws indirectly that theprevention of 0P is more important than treatment at the same time.4.GuKang has simi1ar effect of Ni1estrio1 on contro1ling the animlweight increasing after their ovaries were removed o 5. GuKng can treatmp and PYomote the heal of the fracture resu1ted by 0P: But when weexplore its mechanism, we can' t analysis one hand just as we analysisthe mechanism of Ni 1estrio1's effect; Based on the review of the previousstudy of GuKang and this experiment, we think GuKang has brokenthrough the theory of wester f1 medicine that just supp1y the deficientsubstance, it gives p1ay to strong POints of formu1ae of TCM Which Inakesthe fOca1 POints stand out and select treatment according todifferentiation o GuKang can regll1ate the Who1e body' ba1ance Y1n andYang. stimu1ate the function of the body, and PI'omote recovery;GuKangaffect severa1 hands j its mechanism may be:(1)Through strengthen kidney, it can recover the function ofhypotha1ams--hypoPlysis--target orggns and increase serum CT. serUmE2 which regU1ate al1d inIProve the hormne in the body o It has the effects1ike hormone to PI'omote the ca1cium dePOsition, suPPress...