Migu The Granules Prevention Of Primary Osteoporosis Mechanism

Object: From the systematic pharmacodynamias, study the prevention and treatment of osteoprosis by Migu Cgranuie evaluate the dine effects and primary mechanism of the drug. Method: Choose Migu Cgranuie to treat 40 parents, Choose Gushukang to treat so osteoporosis patients, the period of taking drugs is 3 months.Measure the Bone mineral density (BMD) of both before-treatment and after? treatment. contrast the content of caceifonin, Bone gla protein, Seram caccium, serum phphoras urinc pyridioiine, Deoxy pyridinoline and activity of Alkaline phosphatase of both before-treatment and after-treatment. Under the experiment condition, measure the PKC activity, subtype expression and proforition of asteoblast-like cells line UMR1O6 by the serum containing Migu in a different concentration. Results: The clinic apparent rate and effective rate of Migu Granule is respectively 80% and 92. 5%. its effects are simulated with the control group (Gu Shu Kang). Migu Granule can increase the BMP of the patient of priming Os, and stimulate the mineralization of the bone, reduce the loss of the bone, increase the levet of Caccitonin and ALP, and regulate the imbalariced condition of secretion of hormone in the body, decrease the levelof orine pyridinoline and Dyr, stimulate the Bone formation, prevent the Bone absorption. improve the microstructure of the Bonetissue. The serum contains of Migu Granule can increase tne pke activity of osteoblast-like cells line UMR1O6 ,and tnis kind of stimulation is mainly conductedby cPKCp,and itcan stimulate the proliferation of osteoblast like cells line. Conclusing: The effect of the prevention and treatment of osteoprosis by Migu Cgranule is apparent. These results evaluate the inportant primary mechanism of the drug.