Effect Of Transfer Factor On Immune Indices And Its Toxicity Test In Chicken

The aim of the test was to research the effect of transfer factor on the production and immune function of broiler and layer and have made the toxicity tests on transfer factor, the result as follows:Experiment 1: Effects of transfer factor on the immune function for broiler chicken Selected 120 one-old-day broiler chicken were divided into 4 groups randomly, with 30 chicken in each group, The first group was fed with basal diet; 2,3,4 were experiment groups, which drench transfer factor and vaccine at the same time, at the 1st day the dose of transfer factor were 0.25,0.5 and 1ml in the 2,3,4 groups respectively; at the 7th day the dose of transfer factor were 0.25,0.5 and 1ml in the 2,3,4 groups respectively; at the 14th day the dose of transfer factor were 0.5,1 and 2ml in the 2,3,4 groups respectively; at the 21st day the dose of transfer factor were 1,2 and 4 ml in the 2,3,4 groups respectively; the experimental stage was 8 weeks. The aim of the test was to research the influence of transfer factor on the production and immune function of chicken. The results show that, the group which added transfer factor can improve the performance of the broiler chicken, On the 28th day, the 4th group's growth weight was higher than the1st and 2nd(P<0.05) groups. There was no difference on the weight of thoracic gland, bursa and spleen (P>0.05),so the effects of transfer factor on organ index should be studied in the future. Though the antibody titer of the experiment groups has no significant difference, the antibody titer was higher in the group which added transfer factor. So the group which added transfer factor can improve the performance and reinforce the immunity of the broiler chicken.Experiment 2: The toxicity of transfer factor in chickenSelected 90 28-old-days AA broiler chicken were divided into 6 groups randomly, with 15 chicken in each group, fed with basal diet; The first group was control group,2～6 groups were experiment groups, the chicken which in different experiment groups drench the different dose transfer factor,2,3,4,5and6 groups drench transfer factor at the dose of 3,6,9,12,and 15ml respectively for one chicken,the experimental stage was 14 days. The aim of the test was to research the security of transfer factor to broiler chicken. The results show that: there was no adverse effect even broiler chicken drench high dose transfer factor, There was no difference on death rate, growth weight and internal organs of the control and experiment groups. So the transfer factor was safe and no toxicity.Experiment 3: Effects of transfer factor on the immune function for layers Selected 120 35-week-days layers were divided into 3 groups randomly, with 40 chicken in each group, fed with basal diet; the first group was control group, 2and 3 groups were experiment groups, which drench transfer factor and vaccine at the same time. The doses of the transfer factor were 1 and 2ml respectively in the 1st and 7th day; to research the effects of transfer factor on immune function of the layer. The results show that, drench transfer factor and vaccine at the same time can significantly improve the antibody level of the inactivated vaccine against avian flu. and NDⅣvaccine, and it also significantly prolong the time than the control group. So the transfer factor can improve the immune function of the layers.