Expression Of Neuropeptide And NADPH Oxidase In Serum Of Aggressive - Induced Arrhythmia Rats And Its Mechanism

Arrhythmia is one of the most common clinical causes of sudden cardiac death。Its incidence continues to increase in recent decades, the formation of younger and younger。Although interventional treatment of arrhythmias such as "radiofrequency ablation, pacemaker implantation therapy," played an important role in the treatment of cardiac arrhythmias, but so far, the treatment of cardiac arrhythmias, is still based on the traditional arrhythmic drugs to improve the effect of arrhythmia but unsatisfactory, in recent years, with extensive medical research, people realized the emotional factor is also an important factor in the pathogenesis of cardiac arrhythmias。Emotions can cause abnormal neuropeptide(Neuropepfide Y, NPY) and reduced nicotinamide adenine dinucleotide phosphate(NADPH) oxidase abnormal release, stimulate physiological and cardiac homeostasis imbalance,that is one of the molecular mechanisms triggered arrhythmia。This problem is solved by the use of emotional irritability stimulation, induced a rapid arrhythmia of rat. Dynamic detection of plasma NPY and NADPH oxidase levels in rats before and after modeling. In the use of drugs interfere NPY and NADPH oxidase expression. In order to confirm the traditional Chinese medicine herbs by dispersing stagnated liver qi for relieving qi stagnation can inhibit the release of too much NPY and NADPH oxidase during emotional stress on myocardial cell damage.This is expected to become a new therapeutic target as arrhythmias.Objective: To investigate t The expressive reduced form ofnicotinamide-adenine dinucleotide phosphate oxidase and neuropeptide Y in oxidative stress injury.Methods: 40 SD rats,by the bowel stimulation,were induced fast arrhythmia. Before and after modeling, the plasma neuropeptide Y( NPY) and(NADPH) changes and the corresponding changes in each period of ECG were recorded. Changes in serum NPY and NADPH was detected by using ELISA method.Results: The plasma NPY and NADPH were increased significantly( P < 0. 01), and this state persisted. ECG was characterized with tachyarrhythmia.Conclusion: Liver controlling dispersion theroy regulating bowel is associated with rapid arrhythmia.The elevation of NPY and NADPH plays an important role in the pathological changes of tachyarrhythmia.