Effect Of Yiqi Warming Yang Drug On Serum IL-4, IL-5 And IFN-γ Cytokines In Patients With Allergic Rhinitis

Objective:Through Yiqiwenyang medicine treatments for lung and kidney Yang deficiency type Allergic Rhinitis patients, and observe the primary symptom of their before and after treatment and whether there is a change, to determine Yiqiwenyang medicine is the clinical curative effect;and testing before and after treatment in patients with serum IL-4,IL-5and IFN-y cytokine levels, to discuss when the lung and kidney Yang deficiency patients which balance of Yin Yang imbalance, above distribution levels of these cytokines,Yiqiwenyang medicine in the treatment at the same time, whether or not to Th1/Th2balance have an impact on.Method:Patients respectively from Sichuan province hospital of Traditional Chinese Medicine and West China Hospital,Sichuan University otolaryngology outpatient and ward service,according to the inclusion criteria to filter, select70patients with standard. Adopt parallel control design, the treatment group35examples, the placebo group35cases, and choice8cases of healthy subjects as control. The treatment group using the mentor experience in the therapy of allergic rhinitis party taken SheTiZhiQiu prescription;the particles placebo group taking the packaging the same. Health group of not taking any medication, a course of4weeks. Compared between the two groups before and after treatment, observe and record the signs and symptoms integral, in the process disease concurrently of change. Respectively before and after extracting patients treated in5ml venous blood, about thirty minutes later, the nature of blood coagulation,2000RPM for20minutes, centrifugal supernatant on collecting,using the method of ELISA on cytokines content detection.Results:Yiqiwenyang medicine can obviously relieve the clinical symptoms in patients with allergic rhinitis,treatment group after treatment the symptoms change significantly in the placebo group, p<0.05, the treatment group after treatment symptoms and signs score decreased significantly in the placebo group, p<0.01, t=-23.92.After1month of follow-up of patients, the treatment group total score p<0.01, has significant meaning. In cytokines detection aspects:patients after taking SheTiZhiQiu prescription can change of serum cytokine levels.Conclusion:Taking SheTiZhiQiu prescription to treat lung and kidney Yang deficiency type the clinical curative effect of the symptoms is effective,and can effectively relieve symptoms in patients with nasal and Yang deficiency. With the increase of treatment, the total effective rate also gradually increase, this confirms is one of the effective methods of Traditional Chinese Medicine in the treatment. After treatment, the serum levels of these cytokine levels, respectively have different change, we think the Th1/Th2ratio is close to balance.At the same time, the patient’s body balance of Yin and Yang are also adjust, that may exist between the contact at a deeper level.