Investigation On Risk Factors Of Mild Cognitive Impairment And Dementia

Objective:To investigate the possible risk factors for MCI and dementia and to provide a basis of the prevention of dementia.Methods:By selecting 112 patients age from 35-90 of neurology III department from July 2013 to January 2015 to take the neurophysiologic test.3 groups were classified according to CDR score, including 21 NC,37 MCI and 54 Dementia. The data analysis was accomplished by the descriptive statistics and Binary logistic regression analysis method of SPSS 22.0 software; Incident rates and relative risk (P＜0.05) express the association of a risk factor for MCI or dementia.Results:A total 112 patients with age from 35-90 have been tested, of which include 50.9% male and 49.1% female, the average level of education was 12.65(±4.69) years and mean age was 69.38(±11.06) years, the accounting for age over 55 of the total number of the patients was 105. Among the 3 groups, there was 37 MCI patients, mean age was 70.92(±8.66)years; 54 Dementia patients, mean age was 71.61(±9.05) years; 21 NC patients, mean age was61.10(± 15.37); There were significant differences of age (P=0.001) from basic information factors by the compare between MCI and NC, Dementia and NC, MCI and Dementia. Result of the Binary logistic regression analysis showed:①.There was a critical significant difference in age by comparing MCI group with NC group(P=0.058), with a Odds Ratio(OR) equals to 1.192; Also significant differences exist while comparing dementia group with NC group (P=0.034), MCI/dementia group with NC group (P=0.039), the OR was 1.113 and 1.140respectively. ②. Multiple factors binary logistic regression analysis between dementia group with NC group (P=0.034), MCI/Dementia combine group and NC group(P=0.039) showed a significant difference in smoking history, the OR was 23.680 and 10.376 respectively.③. There was a critical significant difference in coronary heart disease history by comparing MCI/Dementia combine group with NC group (P=0.059).Conclusion:1. The incidence of MCI and Dementia increased with age.2. Smoking may increase the risk of dementia’s onset.3According to the descriptive statistics analysis, Hypertension, coronary heart disease, hyperglycemia, and type-2 diabetes may have correlations with the onset of dementia.