Study On Syndrome And Syndrome Distribution Of Helicobacter Pylori (Hp) Associated Chronic Non - Atrophic Gastritis

Objectives:The purpose of this study is to discuss the TCM syndromes and syndrome factors of Hp related chronic non-atrophic gastritis (CNAG) through the literature review and clinical research, in order to guide the clinical treatment of this disease and to explore the scientific research method of TCM syndromes.The first part:Literature reviewThe first section:Discuss modern medicine research of CNAG, including the biological characteristics of Hp, the epidemiological characteristics of chronic gastritis, influences, pathogenic mechanism, diagnosis and treatment and other aspects. The second section:The literature research of Hp related chronic non-atrophic gastritis. Statistical analyzed 25 articles contain 4545 cases. The results demonsrated that:the syndrome of disharmony between liver and stomach is the most common syndrome, which accounted for a proportion of 24.81%, followed by The weakness of the spleen and stomach syndrome, dmp heat in spleen and stomach,sagnated heat of liver and stomach syndrome, liver stagnation and spleen deficiency syndrome, stomach yin deficiency syndrome, gstric blood stasis syndrome. The syndrome factors of disease location are the stomach, spleen, liver; qi stagnation, Qi deficiency, yin deficiency, heat, dampness are the most common excess factors of the disease.The second part:Clinical studyThe object of study:total 425 cases collected from Dongzhimen hospital, Eastern Hospital, Wangjing Hospital and The Third Affiliated Hospital of BUCM.151 Hp+ cases, and 274 Hp-cases are included.Research methods:On the basis of literature review, we designed the case report form and then collect the all the necessary information such as the clinical information of the patients, and gstroscope inspection report. We applied in EpiData3.1 as the database and SPSS17.0 as statistical analyize software.Results:In 425 cases of CNAG patients, Hp+ 151 cases oocurepried 35.53%; while 274 cases are Hp-took the share of 64.47%. Male 157 cases, female 268 cases, minimum age is 18, and maximum is 75 years old, the average is 40.39. There were 52 cases of patients with smoking history, and 52 cases with drinking history; the infection rate of Hp was 36.54% and 40.38% respectively.Statistical analysis illstrated that gender, age, smoking history, work intensity had no obvious correlation with Hp infection.Hp related CNAG, the main location factors are spleen stomach,liver; and Deficiency of Qi, Stagnation of Qi, dampness, heat are the main excess factor. Classification of syndromes:Heat stagnation of liver and stomach, spleen and stomach deficiency, spleen deficiency and qi stagnation syndrome, liver stagnation and spleen deficiency syndrome, spleen stomach damp heat syndrome; CNAG without Hp Infection, the main location factors are stomach,liver, spleen; and Deficiency of Qi, Stagnation of Qi, dampness, heat are the main excess factor. Classification of syndromes: Spleen deficiency and qi stagnation syndrome, liver stomach heat stagnation, disharmony between liver and stomach, spleen, liver and spleen damp heat syndrome. Hp+ Deficiency and excess inclusion syndrome is more and Hp-The empirical syndrome is more.Conclusion: ① Hp related CNAG, the main location factors are spleen stomach, liver, and Deficiency of Qi, Stagnation of Qi, dampness, heat are the main excess factor. Classification of syndromes:Heat stagnation of liver and stomach, spleen and stomach deficiency, spleen deficiency and qi stagnation syndrome, liver stagnation and spleen deficiency syndrome, spleen stomach damp heat syndrome; ② Athenia and sthenia of the TCM syndromes of CNAG was connected with Hp infection. ③ Ecess factor wet is more in Hp+, The pathogenic characteristics of Helicobacter pylori with dampness pathogen.④ Gender, age, smoking and drinking history, there were no obvious correlation with Hp infection. Hp infection may have a positive correlation with the sweet and the vegetarian diet. ⑤ Syndrome factor differentiation is the more intuitive, accurate and more simple differentiation method.