The Curative Effect Comparison About Disease Differentiation Based On The Specified Prescription And Treatment Based On Syndrome Differentiation Towards The Combination Model Of Disease And Syndrome Of Alcoholic Hepatic Injury

Objective: Through investigating the effect of Weiganjiangmei prescription and treatment based on syndrome differentiation about combination model of disease and syndrome of alcoholic hepatic injury, explore its functional mechanism about anti-hepatic injury and advantages and disadvantages, summarize the prevalent treatment routine and provide the experimental and theoretical basis for standard medication. Methods: 200 Wistar male rats with alcohol intragastric administration. Produced the endoretention of damp heat and stagnation of liver-qi and deficiency of spleen model rats which were treated by TCM classical Prescription, specified prescription based on disease differentiation to compare effects. Through micro view to analyze the Weiganjiangmei Prescription advantages and disadvantages as well as its mechanism. Results: Successfully produced the endoretention of damp heat and stagnation of liver-qi and deficiency of spleen combination model rats of disease and syndrome of alcoholic hepatic injury .Weiganjiangmei decoction as well as specified prescription based syndrome differentiation had obvious therapeutical effect. In all the endoretention of dampheat treatment groups,Longdanxiegan decoction combined with Yinchenhao decotion could reduce the liver index,lowered down the GGF,FFA changed the liver structure.Weiganjiangmei combined with Longdancan Cheqiancao groups could effectively cut down the content of TNF and LEP. In the histopathologic examination,Weiganjiangmei group outweighed the other groups.In the stagnation of liver qi combined with deficiency of spleen group,Weiganjiangmei combined with Chaihu Yiren outweighed the other groups in the total curative effect.It showed that different treatment had its own advantages. In all the Weiganjiangmei groups, it had certain curative effect in the side of changing the model rats normal condition,cutting down the content of Glycine aminotransferase and Gluetamic aminotransferase as well as serum radical, enhancing the activity of SOD and GSH, degrading the content of TNF and LEP, inhibiting the expression of CD14 in the liver tissure. It could relieve the hepatocyte inflammation to protect our body. Conclusions: Through the experimental research, during the course of diagnosis and treatment, should follow the principle of treatment based on syndrome differentiation, outstanding the combination of syndrome differentiation and disease differentiation.Pay attention to the combination of macroscopy and microscopy, combination of phase-medication and cycle medication, combination of four properties five tastes and modern pharmaco-research. On the other side, on the basis of syndrome, according to the syndrome differentiation, referring to TCM classic prescription, it has more advantages.