Research On The Clinical Effect Of Yi Shen Antihypertension Granule (YSAG) Treating Kidney Qi Deficiency Syndrome Of Elderly Hypertension And The Impact Of Sex Hormones

Objective: To evaluate the curative effect of YSAG treating kidney qi deficiency syndrome of elderly hypertension and the changes in sex hormones of kidney qi deficiency syndrome of elderly hypertension and the impact of sex hormones.Methods:①In clinical research, 72 patients of elderly hypertension were divided into tentative group and control group at random. Each group has 36 cases. The tentative group was treated by YSAG, and the control group was treated by compound reserpine tablets. 28 days was a course of treatment. Before treatment, 7 day after treatment, 14 day after treatment, 28 day after treatment, casual blood pressure （CBP） were measured. Before and after treatment, ambulatory blood pressure monitoring （ABP）, blood lipids, blood glucose, EKG, integral of symptoms of Traditional Chinese Medicine （TCM）, integral of syndrome of TCM, integral of quality of life assessment were measured to value the curative effect of YSAG treating kidney qi deficiency syndrome of elderly hypertension.②30 cases healthy aged persons （15 males and 15 females） were selected as the normal control group, sex hormones （E₂, T, FSH, LH, T/E₂） were measured. From the tentative group, 15 males and 15 females of kidney qi deficiency syndrome of elderly hypertension were selected as control group, sex hormones （E₂, T, FSH, LH, T/E₂） were also measured before arid after treatment. So the impact of sex hormones was observed.Results:①YSAG has obvious effect on lowing the blood pressure, against myocardial ischemia, improving glucose and lipid metabolism, improving the patients clinical symptoms, decreasing the clinical symptom score and improving the quality of life.②The level of T and T/E₂ of kidney qi deficiency syndrome of male elderly hypertension was lower than healthy aged persons. The level of E₂ of kidney qi deficiency syndrome of female elderly hypertension was lower than healthy aged persons, the level of T/E₂ was higher than healthy aged persons. After treatment, the level of T and T/E₂ of kidney qi deficiency syndrome of male elderly hypertension was improved, the level of E₂ of kidney qi deficiency syndrome of female elderly hypertension was improved, the level of T/E₂ was lower.Conclusion: The YSAG is a group of effective drugs treating kidney qi deficiency syndrome of elderly hypertension. Besides of lowing the blood pressure, improving the clinical symptoms and quality of life, improving disturbance of sex hormone.