Effects Of Self-control Exercise On Immunity Of Malignant Tumor Patients During Rehabilitation Stage After Surgery

Objective:The aim of this study was to make it clear the effect of Self-Control Exercise on erythrocyte immunity, antioxidant function of erythrocyte, subsets of lymphocyte and relative factors in serum on malignant tumor patients during their rehabilitation stage after surgery, which could offer a guideline for cancer patients to improve health after conventional therapy, and try to enrich refernce material about study on physical activity and cancer rehabilitation.Setting and participants:1 Participants: 40 new malignant tumor patients were recruited from Shanghai Cancer Club, of which there were 17 men (aged from 42 to 71 years old ) and 23 women(aged from 48 to 66 years old). The mean cancer age of them all was 1.50±0.77years, and the type of tumor included breast cancer (17 patients), digestive cancer (14 patients) and others including ovary cancer, lung cancer, thyroid gland cancer, sarcoma,and prostate cancer). All the patients were diagnosed pathologically and were treated with surgery and chemotherapy. They were all willing to participate in this study, After signing their names on informed consent form, they performed 24-week moderate intensive training program of Self-Control Exercise.2 Protocal: After conventional treatment of surgery and chemotherapy, all the patients learned to practice Self-Control Exercise for 3 weeks, then they left the club and began to do exercise regularly for two stages, and the fist stage lasted from 0 or 12th week while the second stage was from the 13rd to 24th week. The patients finished Self-Control Exercise about 5 days per week and each day the total exercise time was about 2 hours.3 Following-up: Going to the park to meet them and providing help on exercise and medical supervision to them.4 Main outcomes: Erythrocyte CD35, erythrocyte CD58, lymphocyte CD3~+, CD3-/CD16~+CD56~+NK and CD3~+/CD16~+CD56~+ NKT were measured by the method of flow cytometry; the activity of erythrocyte SOD , E-GSH-Px were tested by xanthine oxidase and DTNB respectively, plasma MDA was measured by thiobarbituric acid and serum?-EP and IL-2 was measured by ELISA.Results:1 Effects of Self-Control Exercise on erythrocyte CD35 and CD58 in malignant tumor patients during rehabilitation stage after surgery.. The count of red blood cell, level of hemoglobin and hematocrit did not change significantly after 12 or 24 weeks'exercerse in malignant tumor patients after surgery during rehabilitation.(P>0.05).Erythrocyte CD35 increased significantly after 12 weeks'intervention (P<0.01), it attenuated in the 24th week compared with 12th week(P<0.01), however, it still remained a higher level than that before experiment(P<0.01). Erythrocyte CD58 decreased significantly after 12-week's intervention (P<0.01), while it increased in the 24th week compared with that of the 12th week (P<0.01) and there was no significant difference between 0 and 12 week.2 Effects of Self-Control Exercise on erythrocyte antioxidant in malignant tumor patients during rehabilitation stage after surgery.The activity of erythrocyte SOD increased significantly after the patients took 12-week's exercise (P<0.01), though it decreased in the 24th week.(P<0.01), it still remained a higher trend compared with that before experiment(P>0.05).The activity of erythrocyte GSH-Px kept an increasing trend during the 12- and 24-week's Self-Control Exercise intervention, however, there was no significant difference between the 12th and 0th week, 24th and 0th week..Plasma MDA of patients both at the 12th week and 24th week after exercise intervention was much lower than 0 week respectively(P<0.01, P<0.01), though there was no significant difference between 12th and 24th week.3 Effects of Self-Control Exercise on lymphocyte subsets in malignant tumor patients during rehabilitation stage after surgery..Peripheral blood CD3~+ did not change significantly after 12-week's exercise intervention (P>0.05), while it increased significantly in the 24th week (P<0.01). CD3-CD16~+CD56~+NK increased significantly in the 12th week compared with 0 week (P<0.05), and in the 24's week, it was not only higher than 0 week (P<0.01), but higher than the 12th week (P<0.05).NKT increased significantly in the 12th week after exercise intervention (P<0.05), however it had a decreasing trend in the 24th week (P>0.05), but it still showed a little higher than the 0 week (P>0.05).4 Effects of Self-Control Exercise on serum?-EP and IL-2 in malignant tumor patients during rehabilitation stage after surgery..Serum?-EP and IL-2 both had an increasing trend after 12-week's exercise intervention, though it had no significance statistically(P>0.05, P>0.05). And serum?-EP in the 24th week decreased significantly compared with the 12th week, (P<0.01), however it has no difference compared with the 0 week (P>0.05); serum IL-2 still kept an increasing trend in the 24th week, though there was no significant difference between 0 week and 24 week (P>0.05).Conclusions:1 24-week's Self-Control Exercise could improve erythrocyte CD35 in malignant tumor patients after surgery, which might help erythrocyte to execute its immune function, however, erythrocyte CD58 had no significant change after 24-week's Self-Control Exercise intervention.2 24-week's Self-Control Exercise could increase activity of erythrocyte antioxidant in malignant tumor patients after surgery, and decrease the level of plasma MDA, so that it could help the body to avoid damage from oxidative stress and keep an internal environment homeostasis.3 24-week's Self-Control Exercise could increase the level of peripheral blood CD3~+, NK and NKT in malignant tumor patients after surgery, which indicates an improved immune supervision and immune cytotoxicity.4 There was no significant effect of 24-week's Self-Control Exercise on serum?-EP and IL-2 in malignant tumor patients after surgery during rehabilitation..