Photoresponsive Porous ZnO Based Broad-Spectrum Venoms First-Aid Treatment

Venomous snakebite is an emergency of surgical poisoning.The official first aid principle is to reduce the spread of toxins and use the corresponding antivenom serum.However,antivenom is rare in variety,difficult to produce and preserve,and almost impossible to be used for treatment in the first time.Therefore,it would be of great significance to develop convenient,efficient and broad-spectrum snake venoms neutralizing nano-materials,for the research into new drugs to treat snakebite.In this study,inspired by boiled eggs,a new concept based on Zn O complex(ZC)for the treatment of snake venoms was proposed.In vitro and in vivo adsorption experiments proved that ZC could widely adsorb biological(including snake)venoms and effectively reduce the concentration of toxic protein in blood.More importantly,ZC could realize photothermal conversion under the stimulation of near-infrared(NIR)irradiation,resulting in protein hydrolyzation of snake venoms,thereby further prolonging survival time and reducing mortality of animals.In addition,ZC not only showed good biocompatibility,but also could inhibit bacterial reproduction,alleviate inflammation,and contribute to the healing of open wounds caused by biological venoms.