Clinical Study On Acupoint Embedding Therapy For Pre-diabetes

ObjectiveThis study was to observe the clinical efficacy and safety of acupoint embedding therapy in the treatment of pre-diabetes.Randomized controlled trials were conducted to observe pre-diabetes patients receiving acupoint embedding therapy and control patients receiving diabetes health education,and to select common acupuncture points for common acupuncture.Patients in the group received different treatment regimens and improved their blood glucose levels,compared the clinical efficacy of different regimens,and provided new clinical treatment options for the clinical treatment of pre-diabetes.Methodsresearch methodAll cases in this study were from the outpatient department of the acupuncture department of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine.Case collection time is December 2017-2018.The enrolled 90 cases were divided into 30 groups in the treatment group,30 in the A control group and 30 in the B control group according to the random sequence number generated by the random sequence software.The specific method is as follows:a random sequence software template is used to generate a group 1-The random sequence number of 90(that is,the natural number of 1-90,but the order is randomly scrambled).Then,each patient was assigned a random sequence number,the value of which was divided by 3,the remaining 1 into the treatment group,the remaining 2 into the A control group,and the remaining 0 into the B control group.If a patient is assigned a number of 32,except for 3 or 2,the patient is assigned to the A control group.Fill in the random card according to the random sequence number and put it into the corresponding numbered envelope,and keep it in a special person.After the case meeting the inclusion criteria,the envelope number is opened in turn and the treatment on the random card is accepted.treatment methodBasic treatment:All 90 cases were given diabetes health lectures,and according to the 2007 edition of the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China,life interventions were designed and implemented for patients.Life intervention measures:1 daily 3 meals,low fat diet with fat content<25%;2 physical exercise increased to 250?300min per week,the intensity of exercise is less than the maximum oxygen uptake[(220-age)X 60 50%of%],no symptoms such as wheezing and dizziness after exercise,and no adverse reactions such as fatigue and fatigue after awakening the next day.Exercise time is 30?60min each time,3 times a week or once every other day,overweight 5 times a week or once a day;3 control weight,make BMI reach or close to 24;4 quit smoking,limit drinking,intake Alcohol<10g/day.Treatment group interventions:Acupoint embeddingSelection of points:Acupuncture group 1:spleen,stomach,Shenshu;group 2:Yinlingquan,Zusanli,Hong LeongOperation:The patient takes the prone position and fully violently rubs the back or lower limbs.First use the local skin disinfection of the iodophor point,select the disposable injection needle(No.7),and select the poly-p-dioxanone(PPDO)line independently developed by Tianjin Southeast Hengsheng Medical Technology Co.,Ltd.(cut the line body)For a length of about 1.5 cm,take a PPDO thread,clamp one end with a disposable tweezers,and thread the other end into the tip of the needle(peel 1 cm,ie the part of the wire is exposed outside the core).Use your left hand to pinch the skin of the patient' s acupuncture points,hold the needle with your right hand,and quickly penetrate the skin.The direction of acupuncture and the skin can be at an angle of about 75 degrees.The needle is inserted into the spine.The needle is inserted into the needle about 3-4cm according to the patient' s physical condition.When the patient has a soreness,the needle is rotated for one week,and the needle is slowly pulled out.It can be pulled by the muscle fibers or tissue to retain the inside of the acupuncture points.Treatment:once every three days(and then rest for 1 day),continuous treatment for four weeks for a course of treatment,a total of three courses of treatment,and acupoints embedding acupuncture points alternately used.A control group interventions:Selection of points:Acupuncture group1:spleen,stomach,Shenshu;group2:Yinlingquan,Zusanli,Hong LeongOperation:The patient selects the corresponding position(prone position or supine position)and selects Huaying brand acupuncture needle(specification 0.30mm*40mm).After the conventional disinfection of the acupuncture points,the above acupuncture points are straight into the needle.The depth of the needle is about 25mm-30mm depending on the patient ' s physical condition.After the needle is inserted into the needle,the needle is given to the flat and the needle is applied once every 10 minutes.Three times,leave the needle for 30 minutes.Treatment:once every three days(and then rest for 1 day),continuous treatment for four weeks for a course of treatment,a total of three courses of treatment,and acupoints embedding acupuncture points alternately used.B control group interventions:Means:Only the basic treatment intervention was given to the patients,and the monthly control group was given diabetes knowledge publicity and education for 3 times.Encourage patients to record daily diet diaries and check them once a week.Observation indicators and scoring criteria(secondary efficacy indicators)Oral Glucose Tolerance Test(OGTT):Fasting(FPG)and 2 hours postprandial blood glucose(2hPG):Once every 2 weeks,the Japanese-made Hitachi-7070 automatic biochemical analyzer is applied.Glycated hemoglobin(HbAlc):1 time before and after treatment.A high-pressure liquid phase fully automated glycated hemoglobin analyzer manufactured by Bio-Rad.Statistics by measurement data.Clinical symptom scores:This paper is based on the Guidelines for Clinical Research of New Drugs in Traditional Chinese Medicine" and the clinical manifestations of this disease(see Appendix).Because the rating scale involves multiple subjective index evaluations,a person with relevant knowledge of TCM is' assigned to collect the patient-related symptoms at the time of evaluation,and the responsible evaluator does not know the number of random sequences and the corresponding patient grouping.Try to ensure the objectivity,scientificity and uniformity of the collected information.Efficacy criteria(main efficacy indicators)According to the "2002 Chinese Medicine New Drug Clinical Research Guidelines with reference to relevant literature,determine the efficacy judgment criteria and safety evaluation criteria:calculation formula:efficacy index=(pre-treatment score-post-treatment score)/pre-treatment score X 100%.Significant effect:fasting plasma glucose(FPG)and plasma glucose(2hPG)decreased to the normal range 2 hours after glucose load;the clinical symptoms and signs of TCM were significantly improved,and the syndrome score was reduced by?70%.Effective:FPG and 2hPG decreased more than 20%before treatment,and did not reach the normal range.The clinical symptoms and signs of TCM were better than before,and the syndrome score was reduced by?30%.Invalid:FPG and 2hPG did not decrease,or the decline did not reach the effective standard.The clinical symptoms and signs of TCM were not significantly improved or even worse,and the syndrome score was reduced by less than 30%.Statistical methodThe data of this study were statistically analyzed using the statistical software SPSS19.0.The measurement data satisfies the description of the normal distribution.At the same time,two independent samples satisfying the homogeneity of variance are tested by two independent samples t test,and multiple independent samples are analyzed by one-way ANOVA.The Dunnett test was used for the comparison between the group and the control group,the X2 chi-square test was used for the count data,the M(P25,P75)was used for the non-normal distribution,and the non-parametric test based on the rank was used for the statistical method.Resu tsIn the early stage of the enrollment,the patient ' s condition was fully understood,including the address,nature of work,condition and living conditions,and the patient ' s compliance was ensured as much as possible.Therefore,all patients enrolled in the whole process of treatment were in good compliance.Shedding and discontinuation cases occurred,so the valid data of 90 cases were all included in the statistical analysis.There were no significant differences in the distribution of age,sex,height and weight between the three groups before treatment(P>0.05),all of which were comparable.1.After treatment,the total effective rate was 93.3%,the total effective rate of A control group was 83.3%,and the total effective rate of B control group was 60%.The overall curative effect of the treatment group was significantly better than that of the A control group and the B control group.Statistical significance P<0.01.2.After 2 weeks of intervention,there was no significant decrease in FPG and 2hPG in the 3 groups compared with before treatment(P>0.05),and the difference was not statistically significant.3.After 4 weeks of intervention,the FPG(6.42±0.24)index decreased significantly in all three groups compared with before treatment(6.60±0.22).The difference of FPG in the treatment group was significantly lower than that before treatment(P<0.01).The FPG in the A control group(6.52±0.18)was significantly higher than that before treatment(6.64±0.19).The difference(P<0.05)was statistically significant.The difference of FPG in the B control group(6.58±0.18)was significantly lower than that before treatment(6.67±0.16)(P<0.05).4.After 6 weeks of intervention,the FPG index decreased significantly in all three groups compared with before treatment.The difference of FPG(6.28±0.25)in the treatment group was significantly lower than that before treatment(P<0.01).The FPG(6.43±0.19)in the control group was significantly higher than that before treatment.The difference of P<0.01 was statistically significant.The difference of FPG in B group(6.49±0.21)was significantly lower than that before treatment(P<0.01).The difference of 2hPG in treatment group(8.26±0.47)was significantly lower than that before treatment(P<0.01).5.after 8 weeks of intervention,compared with before treatment,the treatment group FPG(6.12±0.25)and 2hPG(8.04±0.43)were significantly decreased compared with before treatment,the difference was statistically significant(P<0.01);A control group FPG(6.33±0.22)decreased significantly compared with before treatment,the difference has statistics The significance of learning(P<0.01);FPG in the control group(6.43±0.25)was significantly lower than that before treatment,the difference was statistically significant(P<0.01);the 2hPG in the B control group(8.41 ±0.51)was significantly lower than that before treatment,the difference was statistically significant(P<0.05).)6.After 10 weeks of intervention,compared with before treatment,the FPG(5.96 ±0.28)and 2hPG(7.83±0.42)in the treatment group were significantly lower than before treatment,the difference was statistically significant(P<0.01);the FPG(6.21±0.25)in the A control group was significantly lower than before treatment,and the difference was statistically significant.The significance of learning(P<0.01);2hPG(8.29±0.60)in the control group was significantly lower than that before treatment,the difference was statistically significant(P<0.05);the FPG(6.38±0.31)and 2hPG(8.31±0.49)in the B control group were significantly lower than before treatment,and the difference was statistically significant(P<0.01).7.After treatment,compared with before treatment,the FPG(5.83±0.31)and 2hPG(7.64±0.41)in the treatment group were significantly lower than before treatment,the difference was statistically significant(P<0.01).The FPG(6.11±0.31)and 2hPG(8.18±0.60)in the control group were significantly lower than before treatment.Statistically significant(P<0.01);FPG(6.31±0.35)and 2hPG(8.241-0.46)in the B control group were significantly lower than before treatment,and the difference was statistically significant(P<0.01).8.After 12 weeks of treatment,the HbAlc in the treatment group(5.77±0.43)and the A control group(6.33±0.36)decreased significantly before treatment,and the difference was statistically significant(P<0.01).ConelusionThrough clinical trials,acupoint embedding was used to compare other basic therapies,and blood glucose-related indicators and overall symptom improvement were observed.It was found that acupoint embedding therapy was superior to ordinary acupuncture treatment and general basic intervention therapy,and blood glucose showed obvious decline.And related symptoms have been significantly improved,can provide a new clinical reference treatment for the treatment of pre-diabetes.