Evaluation Of Traditional Chinese Medicine On Acute Cerebral Infarction With Diabetes Mellitus Based On Data Mining

Objective:1.Through the existing clinical evidence collection,collation,analysis,clea r the combination of Chinese and Western medicine treatment is effecti ve and safety in the treatment of acute cerebral infarction with diabete s.2.With the Apriori algorithm and Kohonen modeling method of artificial i ntelligence,prescription rule mining in treatment of acute cerebral infarc tion with diabetes;through drug resistance,frequency,flavor,channel tr opism,efficacy analysis study on acute cerebral infarction with diabetes syndromes and syndrome distribution characteristics,preliminary clear prescription prescription in treating acute cerebral infarction with diabete s,for clinical application of cerebral infarction with diabetes to provide reference.Method:1.Meta analysis Meta analysis of domestic and foreign databases for literature search,manu al search of relevant information,collection of integrated traditional Chines e and Western medicine treatment of acute cerebral infarction with diabetes literature.To meet the inclusion criteria of literature,based on the use of drugs of different classification,using Stata MP 14 meta analysis,grouped according to the prescription of traditional Chinese medicine and traditional Chinese medicine + western medicine treatment based on RR and SMD,t he effect of the two groups of patients were collected,mortality rate,effici ency,quality of life score,symptom score and nerve defect blood glucose,blood lipid,blood rheology,inflammatory factors and adverse reaction ind ex.2.Data Mining Research The research of data mining in accordance with the inclusion criteria based prescription database,collect the relevant information in general,cerebral i nfarction onset time,duration of diabetes,clinical indicators,the use of dru gs,medicines,drug resistance,frequency tropism,efficacy analysis,the use of network node,Apriori algorithm,Kohonen algorithm and modeling met hod of artificial intelligence.The clinical characteristics of the patients with acute cerebral infarction and diabetes research in law,and the relationship with clinical features and treatment of clinical indicators.Result:1.Meta analysis(1)A total of 104 clinical trials were included,including 10366 patient s in the treatment group and the control group with a total of 5125 patien ts(n = 5011).Most of the literatures included B grade,and there was a moderate risk bias.(2)Compared with the basic treatment of Western medicine,traditional Chinese medicine and Western medicine group,the efficiency of the combi ned effect of the amount of [RR=1.122,95%CI(1.077,1.168,P<0.05]);NHI SS integral combined effect of the amount of [SMD=-1.385,95%CI(-1.732,-1.038),P<0.05];NFDS integral combined effect of the amount of [SMD=-1.266,95%CI(-1.578,-0.955),P<0.05];TCMS integral combined effect of the amount of [SMD=-1.028,95%CI(-1.431,-0.625 P<0.05];BI),integral[SMD=1.029,95%CI(0.889,1.170),P<0.05] [SMD=1.191,95%CI(1.077,1.305);ADL integral,P < 0.05];blood glucose FPG combined effect of the a mount of [SMD=-0.822,95%CI(-1.068,-0.575),P<0.05];2h-PBG combine d effect of the amount of [SMD=-0.966,95%CI(-1.343,-0.589),P<0.05];Hb A1 c combined effect of the amount of [SMD=-0.71,95%CI(-1.18,-0.24),P<0.05] TC;the combined effect of the amount of [SMD=-0.523,95%CI(-0.656,-0.391),P<0.05],TG combined effect of the amount of [SMD=-0.523,95%CI(-0.712,-0.286,P<0.05];LDL-C The combined effect of the am ount of [SMD=-0.42,95%CI(-0.51,-0.33,P<0.05];blood viscosity high shear combined effect of the amount of [SMD=-1.229,95%CI(-1.669,-0.790),P<0.05] IL-6;the combined effect of the amount of [SMD=-1.33,95%CI(-2,-0.65),P<0.05],TNF-a combined effect of the amount of [SMD=-3.32,95%CI(-8.72,-2.08,P<0.05]);the adverse reaction of the combined eff ect of the amount of [RR=1.082,95%CI(0.24,1.39,P=0.22]).(3)Compared with the basic treatment of Western medicine,Chinese m edicine and Western medicine treatment group curative effect combined effe ct of the amount of [RR=1.13,95%CI(1.07,1.19),P<0.05];NHISS integral combined effect of the amount of [SMD=-1.31,95%CI(-1.75,-0.86),P<0.05];NFDS integral combined effect of the amount of [SMD=-1.68,95%CI(-2.45,-0.91),P<0.05];ADL combined effect of the amount of [SMD=0.84,95%CI(0.38,1.30),P<0.05];the combined effect of the amount of [SMD=-0.65,95%CI FPG(-1.57,0.28),P<0.05];2h-PBG combined effect of the am ount of [SMD=-1.33,95%CI(-1.73,-0.93),P<0.05],Hb A1 c combined effect of the amount of [SMD=-0.58,95%CI(-0.90,-0.26,P<0.05],TC);the co mbined effect of the amount of [SMD=-0.53,95%CI(-0.78,-0.28),P<0.05];TG combined effect of the amount of [SMD=-1.1,95%CI(-1.84,-0.35,P<0.05];LDL-C the combined effect of the amount of [SMD=-0.93,95%CI(-1.34,-0.52,P<0.05];whole blood viscosity at low shear combined effect o f the amount of [SMD=-1.21,95%CI(-1.65,-0.76),P<0.05];high shear wh ole blood viscosity The combined effect of the amount of [SMD=-1.83,95%CI(-2.51,-1.14),P<0.05] blood viscosity;the combined effect of the a mount of [SMD=-1.19,95%CI(-1.76,-0.61),P<0.05] hs-CRP;the combined effect of the amount of [SMD=-1.56,95%CI(-2.29,-0.84),P<0.05] IL-6;the combined effect of the amount of [SMD=-1.20,95%CI(-1.64,-0.75),P<0.05];TNF-a combined effect of the amount of [SMD=-1.01,95%CI(-1.79,-0.23,P<0.05]);the adverse reaction of the combined effect of the amount of [RR=0.86,95%CI(0.46,1.61),P=0.64].2.Data Mining Research(1)In patients with acute cerebral infarction with diabetes at the age of(61.45 +4.24)years of age,the proportion of women was(0.435 + 0.091),the proportion of patients with acute cerebral infarction onset time of 14 d is highest,the highest proportion of patients with diabetes duration 5-10 years.(2)The ten most commonly used drugs in the prescription for astragalus root,earthworm,Rhizoma Chuanxiong,radix rehmanniae,radix paeoniae rubra,angelica,peach kernel,safflower,danshen root,leech.Blood stasis,tonifying Qi,tonic drugs,heat clearing drug pingganxifeng drugs,tonifying yin tonic for the high frequency of drug type.Through the meridians high frequency medicine effect,heat and cooling blood,dispersing blood stasis and relieving pain,promoting blood circulation and removing blood stasis,Qi sun use.High frequency,bitter taste,pungent,sweet salty drug use.A mild,slightly cold,temperature and drug use of high frequency of lukewarm.The highest frequency of drug use in liver.(3)A total of 5 kinds of commonly used prescription treatment,respectively,Yiqi Huoxue Qingrejiedu,Jianpi Tongluo,liver Yang Zhen and Zhenganxifeng method,of which the most frequently used method of Supplementing Qi and activating blood.With the party,the use of Nourishing Yin Huoxue Tongluo Decoction and Buyanghuanwu decoction five most frequently.(4)The modeling results of the Apriori algorithm,Shichangpu,calamus,Rhizoma Chuanxiong;Radix Astragali;Radix Puerariae,Radix Astragali,Radix Astragali;leech;safflower and peach kernel is commonly used for treatment.Shi Changpu,astragalus,salvia,astragalus,Shichangpu;Radix Rehmanniae;calamus,astragalus,Radix Astragali,Rhizoma Chuanxiong,Rhizoma Chuanxiong;Radix Puerariae;safflower,peach kernel,red peony root as common medicine group.(5)The results of cluster analysis based on Kohonen modeling were used to obtain the new combinations of traditional Chinese medicine for treating acute cerebral infarction with diabetes mellitus(DM),and to reveal the clinical features of the application of the five new formula.(6)Results showed that the prescription of Nourishing Yin,association graph and Huoxuetongluo Zhuodu with fasting and postprandial 2H blood glucose decreased;of Zhuodu and Fumai Decoction and improve blood lipid;Yang also five soup,Qige Zhidan Tongluo Decoction and improving the blood rheology;Yang also five soup with the level of IL-6 decreased.Conclusion:1 Existing clinical evidence shows that the combination of traditional Chinese and Western medicine treatment of acute cerebral infarction with diabetes can improve neurological symptoms,improve the quality of life score,and improve the clinical indicators.2 Patients with acute cerebral infarction with diabetes age is lower,more common in men,the onset of cerebral infarction after the onset of medication time,more than the diagnosis of diabetes after 5-10 years of stroke.3 Yiqi Huoxue therapy is the most commonly used method of traditional Chinese medicine in treatment of acute cerebral infarction with diabetes.Blood stasis medicine and tonic drugs are commonly used drugs.4 Blood stasis drugs,collaterals the efficacy of drug use of high frequency,the liver by drug use flat rate.5 Association rules to achieve high frequency drug combination and application,may increase the efficacy.6 Cluster analysis to extract the new prescription,according to the basic clinical data suggested the possible application of the law,may provide an important reference for the treatment of acute cerebral infarction with diabetes prescription and the development of new drugs.7 Party,nourishing yin and promoting blood flow of turbid poison may improve blood glucose and lipid levels,Yang also five soup may play effect through improved hemodynamics and inflammatory factor levels.