| ObjectiveBy investigating and analysing the syndrome type,constitution and other influencing factors of Hong Kong women with infertility,the distribution of the constitutional type and the syndrome type of the patients,and the causes of infertility in women were explored.In the research,the association between common syndrome types and constitutional type,as well as that of common syndrome type and various influencing factors were studied and hopefully the result could become the reference for the management and prevention of the infertility in Hong Kong in the future.MethodsThe research was conducted with convenience sampling survey method from January to December 2016.The subjects of the research were the patients of the 10 chinese medicine clinics of the HKFTU Workers' Medical Clinics and Qian Jin Clinic,or the relatives or friends of them that were diagnosed as infertile.Based on the diagnostic criteria,inclusion criteria and exclusion criteria,286 female patients were included in the research.Questionnaire was used for data collection and the constitution type and the syndrome type of the patients were determined based on the Classification and Determination of Constitution in TCM and the Guidelines for Diagnosis and Treatment of Common Diseases of Gynecology in TCM respectively.The data was coded and used to make a database and SPSS17.0 was employed to analyse the data.Result301 Questionnaires were given out and 291 were collected.286 one were valid.6 were excluded because the patients failed to provide examination reports for the cause analysis.1.Among the 280 infertile patients which had undergone relevant examinations,60.84%were of primary infertility and 39.16%were secondary.Among them,most were due to ovulation related diseases which included 103 cases(36.79%),82 were due to fallopian tube blockage diseases(29.28%),14 were due to both ovulation related diseases and fallopian tube blockage diseases(5.00%),81 were due to other diseases(28.93%)2.For the syndrome type,most of the infertile patients were of the kidney yang deficiency syndrome(19.93%)and kidney qi deficiency syndrome(19.93%),which were followed by the liver qi depression syndrome(18.53%),kidney yin deficiency syndrome(13.99%),phlegm-dampness obstruction syndrome(13.29%),syndrome of blood stasis obstructing the uterus(11.54%)and dampness-heat binding syndrome(2.8%).3.The age of the patients of different syndrome types were different.The age of the patient of the dampness-heat binding syndrome was relatively younger(32.00 years)and that of kidney yang deficiency syndrome was relatively older(36.40 years).There was statistically significant difference in the age of patients with different constitutional types(P<0.05).For the patients aged less than 35 years,most of them were of liver qi depression syndrome(25.00%).For the patients aged 35 to 40 years,most of them were of kidney yin deficiency syndrome(20.13%).For the patients aged more than 40 years,most of them were of kidney qi deficiency syndrome or kidney yang deficiency syndrome(32.43%for each type).There was significant difference in the age of patients with different syndrome types(P<0.01).4.The duration of disease of the patients of different syndrome types were different.The duration of disease of the patients of dampness-heat binding syndrome was relatively shorter(3 years)and that of blood-stasis type was relatively longer(6 years),and the difference between them were statistically significant(P<0.01).For the patients with the duration of disease less than 4 years,most of them were of kidney qi deficiency syndrome and liver qi depression syndrome(23.47%and 19.39%).For the patients with the duration of disease 4 to 7 years,most of them were of liver qi depression syndrome(22.61%),which was followed by kidney yang deficiency syndrome and kidney qi deficiency syndrome(17.39%and 16.52%).For the patients with the duration of disease 7 to 10 years and that of more than 10 years,most of them were of kidney yang deficiency syndrome(33.33%and 36.84%).There was significant difference in the duration of disease of patients with different syndrome types(P<0.05).5.For the syndrome types of the patients,most of the patients with ovulation related diseases were of the kidney yang deficiency syndrome(22.33%),and least of them were of dampness-heat binding syndrome.There were no significant difference in the number of patients of different syndrome types(P>0.05).Most of the patients with fallopian tube blockage diseases were of the syndrome of blood stasis obstructing the uterus(20.73%),which was followed by kidney yang deficiency syndrome(17.07%),and least of them were of dampness-heat binding syndrome.There were significant difference in the number of patients of different syndrome types(P<0.01).Most of the patients with both ovulation related diseases and fallopian tube blockage diseases were of kidney yang deficiency syndrome and the syndrome of blood stasis obstructing the uterus(28.57%for each type).Most of the patients with other diseases were of kidney qi deficiency syndrome(30.86%),and least of them were of dampness-heat binding syndrome,here were significant difference in the number of patients of different syndrome types(P<0.01).There were no significant difference in comparing the fallopian tube blockage diseases,ovulation related diseases with the syndrome types(P>0.05).6.Considering the influencing factors,there were significant difference in the composition of patients of di f ferent syndrome types in terms of drinking frequency(P<0.01),sleeping quality(P<0.01),time of sleeping(P<0.01)and stress level(P<0.01).There were no significant difference in comparing the syndrome types with the childbirth history(P>0.05),education level(P>0.05),occupation(P>0.05).7.Distribution of chinese medicine constitutional type,in descending order:yang-deficiency type(19.93%),qi-deficiency type(17.83%),qi-depression type(13.99%),yin-deficiency type(11.89%),blood-stasis type(10.14%),gentleness type(8.74%),phlegm-wetness type(8.04%),wet-heat type(4.90%),and special diathesis type(4.55%).8.The age of the patients of different constitutional types were different.The age of the patient of wet-heat type was relatively younger(32 years)and that of yin-deficiency type was relatively older(37 years),and the difference between them were statistically significant(P<0.05).For the patients aged less than 35 years,most of them were of qi-deficiency type and yang-deficiency type(21.00%and 18.00%).For the patients aged 35 to 40 years,most of them were of yang-deficiency type and yin-deficiency type(20.13%and 17.45%).For the patients aged more than 40 years,most of them were of yang-deficiency.type and qi-deficiency type(24.32%and 21.62%).There was no significant difference in the age group of patients with different constitutional types(P>0.05).9.The duration of disease of the patients of different constitutional types were different.The duration of disease of the patients of wet-heat type was relatively shorter(3 years)and that of blood-stasis type was relatively longer(7 years),and the difference between them were statistically significant(P<0.01).For the patients of duration of disease for 1 to 4 years,most of them were of qi-deficiency type and yang-deficiency type(17.35%for each).For the patients of duration of disease for 4 to 7 years,most of them were of qi-deficiency type and yang-deficiency type(20.87%for each).For the patients of duration of disease for 7 to 10 years,most of them were of yang-deficiency type and qi-depression type(24.07%and 20.37%).For the patients of duration of disease for more than 10 years,most of them were of phlegm-wetness type(31.58%).There was significant difference in the duration of disease with different constitutional types(P<0.05).10.For the constitutional types of the patients,most of the patients of ovulation related diseases were of yang-deficiency type(20.51%),which was followed by qi-deficiency type(17.95%).The least were of special diathesis type.There was no significant difference in the distribution of constitutional types(P>0.05).Most of the patients of fallopian tube blockage diseases were of yang-deficiency type(18.75%),which was followed by qi-deficiency type and qi-depression type(15.63%for each).The least were of special diathesis type.There was no significant difference in the distribution of constitutional types(P>0.05).Most of the patients of both ovulation related diseases and fallopian tube blockage diseases were of blood-stasis type(28.57%),which was followed by yang-deficiency type(21.43%).There was no significant difference in the distribution of constitutional types(P>0.05).Most of the patients of other diseases were of qi-deficiency type(19.75%),which was followed by yang-deficiency type(18.52%)and yin-deficiency type(17.28%).There was no significant difference in the distribution of constitutional types(P>0.05).There were no significant difference in comparing the fallopian tube blockage diseases,ovulation related diseases with the constitutional types(P>0.05).11.For the association of the constitutional types and syndrome types of infertile patients:(1)The distribution of syndrome types of gentleness type patients,in descending order,was:kidney qi deficiency syndrome(28.00%),liver qi depression syndrome(24.00%),kidney yang deficiency syndrome(20.00%),kidney yin deficiency syndrome(12.00%),phlegm-dampness obstruction syndrome(12.00%),syndrome of blood stasis obstructing the uterus(4.00%).None of them were of the dampness-heat binding syndrome.(2)The distribution of syndrome types of qi-deficiency type patients,in descending order,was:kidney qi deficiency syndrome(39.22%),kidney yang deficiency syndrome(27.45%),phlegm-dampness obstruction syndrome(11.76%),liver qi depression syndrome(9.80%),kidney yin deficiency syndrome(7.84%),syndrome of blood stasis obstructing the uterus(3.92%).None of them were of the dampness-heat binding syndrome.There was statistically significant difference between different symptom types(P<0.01).(3)The distribution of syndrome types of yang-deficiency type patients,in descending order,was:kidney yang deficiency syndrome(45.61%),kidney qi deficiency syndrome(28.07%),phlegm-dampness obstruction syndrome(17.54%),syndrome of blood stasis obstructing the uterus(5.26%),liver qi depression syndrome(3.51%).None of them were of the kidney yin deficiency syndrome and dampness-heat binding syndrome.(4)The distribution of syndrome types of yin-deficiency type patients,in descending order,was:kidney yin deficiency syndrome(61.76%),syndrome of blood stasis obstructing the uterus(11.76%),kidney qi deficiency syndrome(8.82%),liver qi depression syndrome(8.82%),phlegm-dampness obstruction syndrome(5.88%),kidney yang deficiency syndrome(2.940%).None of them were of the dampness-heat binding syndrome.(5)The distribution of syndrome types of phlegm-wetness type patients,in descending order,was:phlegm-dampness obstruction syndrome(36.78%),kidney yang deficiency syndrome(21.74%),liver qi depression syndrome(17.39%),kidney qi deficiency syndrome(13.04%),syndrome of blood stasis obstructing the uterus(8.70%),dampness-heat binding syndrome(4.35%).None of them were of the kidney yin deficiency syndrome(6)The distribution of syndrome types of wet-heat type patients,in descending order,was:dampness-heat binding syndrome(50.00%),phlegm-dampness obstruction syndrome(21.43%),liver qi depression syndrome(14.29%),kidney yin deficiency syndrome(7.14%),syndrome of blood stasis obstructing the uterus(7.14%).None of them were of the kidney-qi deficiency syndrome and kidney yang deficiency syndrome.(7)The distribution of syndrome types of blood-stasis type patients,in descending order,was:syndrome of blood stasis obstructing the uterus(34.48%),liver qi depression syndrome(21.14%),kidney yang deficiency syndrome(13.79%),kidney yin deficiency syndrome(13.79%),kidney qi deficiency syndrome(10.34%),phlegm-dampness obstruction syndrome(3.45%).None of them were of the dampness-heat binding syndrome.(8)The distribution of syndrome types of qi-depression type patients,in descending order,was:liver qi depression syndrome(55.00%),syndrome of blood stasis obstructing the uterus(22.50%),kidney yin deficiency syndrome(15.00%),phlegm-dampness obstruction syndrome(5.00%),kidney qi deficiency syndrome(2.50%),None of them were of the kidney yang deficiency syndrome and dampness-heat binding syndrome.There was significant difference between different symptom types(P<0.01).(9)The distribution of syndrome types of special diathesis type patients,in descending order,was:kidney qi deficiency syndrome(30.77%),phlegm-dampness obstruction syndrome(23.08%),kidney yang deficiency syndrome(15.38%),liver qi depression syndrome(15.38%),kidney yin deficiency syndrome(7.69%),syndrome of blood stasis obstructing the uterus(7.69%).None of them were of the dampness-heat binding syndrome.(10)Excluding the cases of dampness-heat binding syndrome which were too few,there was significant difference between different constitutional type and symptom types.12.The correlation between constitutional types and common syndrome types of infertile patients:Yang-deficiency type was positively correlated with kidney yang deficiency syndrome.Qi-deficiency type was positively correlated with kidney qi deficiency syndrome.Qi-deficiency type was positively correlated with liver qi depression syndrome and syndrome of blood stasis obstructing the uterus.13.The correlation between common syndrome types and influencing factors of infertile patients:Kidney qi deficiency syndrome was negatively correlated with stress level.Kidney yang deficiency syndrome was negatively correlated with stress level,nevertheless positively correlated with duration of disease.Liver qi depression syndrome positively correlated with stress level.14.The correlation between common types of infertility and influencing factors of infertility:Ovulation related infertility was negatively correlated with positive childbirth history.Fallopian tube blockage infertility was positively correlated with positive childbirth history.Conclusion1.The major chinese medicine syndrome types of Hong Kong female infertile patients were the kidney yang deficiency syndrome and kidney qi deficiency syndrome,which was followed by liver qi depression syndrome.2.The major chinese medicine constitutional types of Hong Kong female infertile patients were the yang-deficiency type,qi-deficiency type and qi-depression type.3.Patients of yang-deficiency type was positively correlated with kidney yang deficiency syndrome.Qi-deficiency type was positively correlated with kidney qi deficiency syndrome.Qi-deficiency type was positively correlated with liver qi depression syndrome and syndrome of blood stasis obstructing the uterus.4.Patients of kidney qi deficiency syndrome was negatively correlated with stress level.Kidney yang deficiency syndrome was negatively correlated with stress level,nevertheless positively correlated with duration of disease.Liver qi depression syndrome positively correlated with stress level.5.The correlation between common types of infertility and influencing factors of infertility:Ovulation related infertility was negatively correlated with positive childbirth history.Fallopian tube blockage infertility was positively correlated with positive childbirth history. |
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