| 1 Purpose and significance of the studyUsually,this is considered to be aging,such as:over sixty years,with white hair,tooth loss,dizziness and deafness clinical manifestations.In fact,aging is a broad concept,and modern studies have found that the process of human aging has started since embryonic development.Aging occurs mainly after the age of sixty,but even in infants and young children can age.In fact,in clinical terms,aging can occur at any age.The characterization of aging can be appearance of aging appearance,can be expressed as internal organs morphology changes,along with the aging of tissues and organs,its function will be a recession and a series of complicated aging related diseases.Therefore,it is important for us to correctly understand the essence and characterization of aging for understanding the related diseases of aging and delaying senility.Medical record is the objective record of TCM clinical practice,recorded the clinical manifestations and signs of patients,embodies the specific application of diagnosis and treatment of traditional Chinese medicine prescription.Study on medical record as the sample data is close to clinical practice.Aging related medical records scattered in the ancient and modern medical records involved in aging aging due to aging,anti senility,syndrome treatment etc.This study through the collection of ancient and modern medical records,medical records related to aging screening,combining database and data mining technology,the aging related medical records makes a comparative analysis of multi-level multi angle,aims to sort out the aging theory of TCM and its origin,to explore the characterization and mechanism of traditional Chinese medicine of aging,aging related diseases and its understanding of the law,should be based on the idea of aging intervention,Hutchinson-Gilford Progeria Syndrome,as a typical case of aging related diseases,to explore the specific application of aging theory of TCM in clinical practice,and the method of early intervention on aging.2 Research methods and content1)Literature study of Chinese medicine theory of aging and anti-aging,from the perspective of the historical development of the system of Traditional Chinese Medicine theory of aging and anti-aging theory,summed up the doctors' understanding of aging and anti-aging in different historical periods.2)Based on the ancient and modern medical records to screening the medical records be related with aging and establish of aging related medical records database.Methods and procedures:Collection of ancient and modern medical records;Establishment of the aging related medical records database standard.The medical records related to aging to be screening based on ancient and modern medical records;Data pretreatment on senescence related medical records were screened out;"Chinese medical records management module of Traditional Chinese Medical knowledge service and sharing system in v1.2.2 as a tool for building data base.3)Aging related medical records data will be used for data mining analysis based on the standard database of medical records related to aging.These aging related medical records in the standard database of data analysis will be added to the pool,and then analyze the data.The data analysis tool is the Traditional Chinese Medical knowledge service and sharing system in v1.2.2 data mining analysis module.The main contents of the analysis consists of three modules,the first module is the frequency analysis,including doctors,disease,symptom,syndrome,drug etc.The second module is the association analysis,including TCM syndromes,diagnosis,treatment and prescriptions,respectively and the association rules between Chinese medicine,and the association between Chinese medicine and Chinese medicine analysis.Also includes the analysis of association between the five internal organs deficient syndrome and symptoms of the patients over the age of 40.4)Based on SPSS 19.0 data analysis tool for the aging related medical records in the standard library of single herb by cluster analysis.3 Results and conclusions of the studyThe medical records collected were collected from ancient to modern books of 681,with aging related medical records of books 251,finally met the inclusion criteria and exclusion criteria of aging related medical records in 1220 cases.1220 cases of aging related medical records in the standard database for data mining analysis,the results are as follows:1.Frequency analysis1)The distribution of TCM diseases:Disease of Traditional Chinese medicine is widely distributed,a total of 375 kinds of diseases,related to the type of subjects have internal medicine,surgerygy,necology,pediatrics,ophthalmology and otorhinolaryngology,dermatology,with medical diseases and gynecological disease is more common.The name of the disease distribution frequency in the top 10 " dysgenesis,dysentery,apoplexia,diarrhea,asthma,sterility,edema,cough,thoracic obstruction,consumption".The distribution frequency of aging related diseases in different age and different,for example:21-30 years old with aging performance of the patients in the distribution of more to infertility,infertility;31-40 years old with infertility,hair loss,insomnia distribution more;aged 41-50 with diarrhea and dysentery distribution more;aged 51-60 in stroke,chest distribution more;aged 61-70 in stroke,the distribution of more cough with cough,asthma;71-80 years old 81-90 years old with more distribution;the distribution of more edema and constipation.2)The distribution of syndromes:the frequency of the top 10 are:kidney yang deficiency syndrome,syndrome of yang deficiency of both spleen and kidney,syndrome of deficiency of both qi and blood,yang deficiency syndrome,kidney qi deficiency syndrome,deficiency of vital energy,syndrome of deficiency of spleen qi and stomach qi,syndrome of deficiency of kidney essence,deficiency of both spleen and kidney and blood stasis.3)Treatment methods:Frequency distribution in the top 10 is "tonifying the spleen and kidney,warmly invigorating kidney yang,tonifying qi and blood,invigorating spleen and replenishing qi,activating blood circulation to dissipate blood stasis,tonifying life-gate fire,tonifying qi of middle-jiao energy,warming the kidney and strengthening yang,nourishing kidney essence,invigorating spleen and kidney;4)Symptoms:Frequency distribution in the top 10 are:thin white fur,pale tongue,deep thready pulse,soreness and weakness of waist and knees,pale,red tongue,lassitude,weakness,emaciation,thready and weakness pulse;5)The distribution of Chinese medicine frequency the top 10 are:radix aconiti carmichaeli,astragalus,ginseng,angelica,codonopsis,bighead atractylodes rhizome,radix rehmanniae praeparata,poria cocos,cassia twig,white peony;The top 12 constitute a new prescription combination:radix aconiti carmichaeli,astragalus,ginseng,angelica,codonopsis,bighead atractylodes rhizome,prepared rehmannia root,poria cocos,cassia twig,white peony,chinese wolfberry,licorice;6)Prescription name:Frequency distribution in the top 10 are:guifudihuang pills,buzhongyi qi decoction,fuzi lizhong decoction and sijunzi decoction,zhenwu decoction,six ingredient rehmannia pill,lizhong decoction,shiquan dabu decoction,guipi decoction,sishen pill.2.Results and conclusions of cluster analysisIn 1220 cases of aging related medical records by cluster analysis,20 kinds of traditional Chinese medicine composition,the first kind is Buzhong Yiqi Decoction and Guipi Decoction prescription,second prescriptions for Guifudihuang pills and Shenqi Pill.Among them,there are 12 kinds of traditional Chinese medicine combinations with tonic effect,accounting for 60%of the total category.In the category of tonic efficacy,tonifying kidney is predominant,followed by invigorating spleen,followed by supplementing qi and blood.3.Association analysis3.1 Association analysis of consilia essential factors and drugs.1)The correlation analysis result can be seen:drugs and drug compatibility,qihm and hematinic medicine such as:astragalus and angelica,licorice and angelica;qihm and qihm combined.Such as:astragalus and bighead atractylodes rhizome,codonopsis pilosula and atractylodes macrocephala;warming yang and invigorating qi medicines,such as aconite and atractylodes macrocephala;the medicine of both warming yang and yang the compatibility,such as:cassia twig and monkshood;medicine compatibility,hematinic and hematinic,such as:white peony and angelica sinensis;tonifying spleen and spleen dampness medicine compatibility,such as:yam and fulling;qihm and spleen dampness medicine compatibility,such as ginseng and fuling;compatibility of drugs such as circulating qi and tonifying qi:tangerine peel and largehead atractylodes rhizome;melting phlegm dampness medicine and spleen dampness medicine compatibility,such as:pinellia and fuling;tonifying kidney essence medicine and invigorating qi and nourishing yin drugs,such as dogberry and yam.The above data shows that the drug in the treatment of aging related diseases,drug compatibility principle is tonifying qi and nourishing blood,tonifying kidney and invigorating spleen.2)The disease name(Chinese medicine diagnosis)and the Chinese medicine name carries on the correlation analysis,the results showed that sterile respectively with Chinese medicine prepared rehmannia root,chinese wolfberry,dodder,a high degree of relevance,and the sterility shudihuang strongly associated,dysentery(chronic dysentery)and dangshen,ginseng,white atractylodes rhizome,radix aconiti and a high degree of relevance,which is strongly associated with root of hairy asiabell,ginseng;diarrhea(chronic diarrhea)and aconite root,ginseng,atractylodes,a high degree of relevance,which is strongly associated with aconite root,ginseng;infertility and prepared rehmannia root,angelica high correlation;edema high correlation with tuckahoe,aconite;asthma a high degree of relevance,ginseng and monkshood;from the associated disease and drugs can be seen,reflected in all aspects of the body aging,which are manifested in different forms of the disease,from disease resistance and efficacy of combined drugs can be seen,aging the essence of the deficiency,and kidney deficiency,spleen deficiency,yang deficiency,qi deficiency and blood deficiency led.3)Syndromes and drug related degree can be seen,kidney yang deficiency and prepared rehmannia root,aconite root,white atractylodes rhizome,cassia twig,dodder,a high degree of relevance,the strong association with rehmannia root,aconite,qi and blood deficiency syndrome and two astragalus,angelica,codonopsis,high degree of relevance,the deficiency of qi and blood and two astragalus and angelica showed strong correlation.Spleen kidney yang deficiency and monkshood,cassia twig,atractylodes,codonopsis,has high degree of relevance,and the relatively strong correlation,guizhi aconite.Yang deficiency of spleen and kidney and monkshoodwith guizhi;yang deficiency with ginseng,dangshen,baizhu fuzi,a high degree of relevance,which is strongly correlated with ginseng,aconite;qi deficiency and ginseng a high degree of relevance;syndrome of deficiency of kidney essence with shudihuang high degree of relevance.4)Treatment from aging related medical records and drug related degree can be seen,tonifying the spleen and kidney showed a strong association with guizhi,nourishing and warming kidney yang was strongly associated with rehmannia root,aconite.This shows that the diseases associated with aging,need wenbushenyang,can be modified first prepared rehmannia root,aconite,for tonifying the spleen and kidney,can be the first choice of cassia twig.3.2 Association analysis of the five internal organs deficiency and symptoms(patients aged 40 or above),the results are as follows:1)Kidney yang deficiency with " edema,palpitations,fatigue,chills,cough,anorexia,dizziness,shortness of breath,limbs cold,backache" has a high degree of association,which "dropsy" and kidney yang deficiency syndrome showed strong correlation.Syndrome of deficiency of kidney qi with "fatigue,palpitation,cough,shortness of breath,backache,fatigue,abdominal distension,lumbago,frequent micturition,anorexia" has a high correlation.The "weak" and kidney qi deficiency syndrome showed strong correlation.Kidney yin deficiency with "dizziness,backache,tinnitus,palpitation,edema,dry mouth,dry throat,dry stool,insomnia,back pain" has a high degree of association,which"dizzy" and kidney yin deficiency syndrome showed strong correlation.Kidney essence deficiency respectively with "tinnitus,palpitation,dizziness,weakness,soreness of waist,insomnia,abdominal distension,hemorrhage,edema,tongue stiff and speech blurring" has high correlation,which "tinnitus,palpitation,dizziness and kidney deficiency syndrome showed a strong correlation with confidence level,the four group of syndrome existed in the "back" symptoms,suggesting that the common characterization of renal aging:soreness of waist,edema,fatigue,palpitations,dizziness,tinnitus.2)Of spleen qi deficiency syndrome respectively with dizziness,lassitude,palpitation,bleeding,thin stool,edema,fatigue,hiccups,diarrhea,shortness of breath,loose "has high degree of correlation,which" dizzy "was strongly correlated with spleen deficiency.Yang deficiency of spleen and kidney respectively with"edema,fatigue,anorexia,chills,palpitations,backache,fatigue,abdominal pain,weight loss has a high degree of association," the"weak" and yang deficiency of spleen and kidney showed strong correlation degree,in addition to spleen yin syndrome associated with symptoms did not appear in the range of minimum reliability and minimum support degree,this shows that over 40 years of age,and both aging related diseases,the common syndromes of the spleen of aging for spleen qi deficiency and yang deficiency of spleen and kidney,spleen common aging is characterized by:dizziness and weakness.3)Correlation analysis between liver deficiency syndrome and symptoms.hyperactivity of liver yang and "palpitations,tinnitus,pain,dizziness,dry mouth,nausea,headache,dizziness,vomiting,weight loss" has high correlation,which is strongly associated with hyperactivity of liver yang in "palpitation".liver kidney yin deficiency syndrome with "heart palpitations,dizziness,dry mouth,dry stool,anorexia,headache,tinnitus,dry throat,mouth pain,knee acid be scanty of words" has high correlation,which"palpitation,dizziness,dry mouth,dry stool and liver kidney yin deficiency syndrome showed strong correlation.in addition related liver blood deficiency syndrome,liver qi deficiency syndrome and symptoms did not appear in the range of minimum reliability and minimum support degree,this shows that over 40 years of age,and both aging related diseases,the common syndromes of the liver of aging for hyperactivity of liver yang and yin deficiency of liver and kidney,common characterization liver aging:palpitation,dizziness.4)Syndrome of heart yang deficiency and "heart palpitations,shortness of breath,chest tightness,cold limbs,fatigue,pain,cough,colic,thin white fur,dark red tongue" has high degree of association,in which the" palpitation "and heart yang deficiency showed strong correlation degree.syndrome of yang deficiency of heart and kidney and "heart palpitations,edema,cough,cold limbs,chills,fatigue,insomnia,asthma,backache,shortness of breath has high degree of association,which" palpitation,edema" and syndrome of yang deficiency of heart and kidney showed strong correlation degree.in addition,the heart yin deficiency and heart qi deficiency syndrome associated with symptoms did not appear in the range of minimum confidence level and minimum support degree,this shows that over 40 years of age,and both aging related diseases,syndromes of cardiac aging heart yang deficiency and kidney yang deficiency of heart,heart is the common characterization of aging:palpitation.This shows that more than 40 years of age,and both aging related diseases,the common syndromes of heart aging for heart yang deficiency and heart kidney yang deficiency syndrome,for the common characterization of heart aging:palpitation.5)Syndrome of deficiency of lung qi and "cough,shortness of breath,palpitation,edema,uroschesis,less abdominal straining,anorexia,wheezing" has high degree of association,which was strongly associated with lung qi deficiency syndrome to" cough".Lung and kidney qi deficiency with "asthma,cough" has a high degree of correlation.The association of lung yin deficiency syndrome and symptoms did not appear in the range of minimum confidence level and minimum support degree,within this range and the symptoms of lung and kidney qi deficiency associated less,this shows that over 40 years of age,and both aging related diseases,syndromes of lung aging for qi deficiency.For the common characterization of lung aging:cough.4 Theoretical considerations1)According to the content of ancient and modern medical records,dynasties as the order of writing,combining with the background,discussed the different historical period of social thought and culture of Traditional Chinese medicine of aging and anti-aging effect and promote the formation of the theory,elaborated the formation due to limitations of the times factors of aging misunderstanding.2)With aging related medical records,and data analysis conclusion,puts forward an important role to play in human vascular senescence in the aging process,and channel senescence order,respectively expounds the Yang Ming channel senescence,Triple Yang channel senescence,Chong Ren Channel Senescence,and pulse aging characterization and mechanism,and channel senescence correlation common disease.3)With age related medical records in 40 years the association between the five internal organs deficiency and symptoms of the results of the analysis,the five internal organs failure order,discuss the characterization of kidney yang,kidney yin,kidney qi,kidney essence,spleen,liver,heart and lung diseases associated with aging and aging of the viscera.In addition,combined with the kidney essence and brain connections,and modern research progress,discusses the aging characterization of brain nerve cells in morphology and the diseases related brain aging.With the aging related medical records data analysis,discusses the importance of protecting kidney yang "in the prevention of aging related diseases.4)According to the contents of aging related medical r ecords and results data analysis,summarizes the law of ag ing related disease categories and aging related disease tr eatment,put forward the concept of "treatment of disease b ased on aging theory",With the typical representative of a ging related diseases in" Hutchinson-Gilford Progeria Synd rome" as an example,combined with modern research progress summarizes the common clinical manifestations and pathogen e-sis of Hutchinson Gilford Progeria Syndrome.Based on stu d—y of aging related medical records conclusion and the com m-on clinical manifestations of Hutchinson-Gilford Progeri a Syndrome,discuss the TCM etiology and pathogenesis of Hu t-chinson-Gilford Progeria Syndrome;according to the know ledge discovery of Chinese herbal medicine in aging related medical records,discussed the new prescription in treatme n-t of Hutchinson-Gilford Progeria Syndrome. |
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