Study Of The Clinical Observation And Empirical On Treating Qixu And Qizhi Type Chronic Functional Constipation(FC) With Chaishao Sijun Jiawei Decoction (Traditional Chinese Medicine)

ObjectiveFunctional constipation is a common clinical disorder of gastrointestinal function,which is characterized by constipation,or defecation time interval extension,difficulties and the meaning is to the disease.Combining literature research and teacher for many years experience in clinical treatment of the common constipation that Qixu and Qizhi,mainly because with the Ganyu and Pixu,Combining literature research and mentors in the clinical experience of treating constipation,withSoothing the liver and invigorating the liver,invigorating the spleen and replenishing qi as the main treatment,proposed " Chaishao Sijun Jiawei Decoction " treatment "Qixu and Qizhi type"Chronic Functional Constipation.On functional constipation of clinical observation and experimental study,to explore the " Chaishao Sijun Jiawei Decoction " effect on the treatment of functional constipation,which will provide a scientific basis for clinical treatment of functional constipation.Methods1.Literature research:on the etiology and pathogenesis of TCM of chronic functional constipation and evidence-based medicine,western medicine of popular sexology,pathogenesis,treatment and so on,analyzed its research.Refer to other test and clinical research,according to the conditions,we now can to develop a complete and scientific test method.2.Clinical research methods:using randomized,controlled method,will be up to the standard of the Chinese and western medicine diagnosis of functional constipation patients into,is divided into two groups,treatment group with " Chaishao Sijun Jiawei Decoction " water decoction,Mosapride will benefit oral control group." Chaishao Sijun Jiawei Decoction " on the clinical effect of the treatment of functional constipation,symptoms improved after treatment efficacy,compared the two groups after treatment to improve curative effect.3.Experimental research methods:hunger disorder,bundling and qi deficiency of excessive fatigue and gas secret model mice,in which based on compound diphenoxylate to create a model of constipation.Divided into normal group,Mosapride will benefit group,model group,high dose group,middle dose group,low dose group,observation " Chaishao Sijun Jiawei Decoction " effect on defecation function in mice.Result1.Clinical research results:through the Chinese medicine group(Chaishao Sijun Jiawei Decoction)and western medicine group(Mosapride)clinical observation," Chaishao Sijun Jiawei " of traditional Chinese medicine group total effective rate was 93.33%;" Mosapride " of the western medicine group total effective rate was 86.67%,the difference is significant(P<0.05).Traditional Chinese medicine and western medicine group after treatment,the stool properties,laborious,defecation time interval,defecation time defecate,abdominal distension,chest side the new full,belching,early enough,nine points of modern depression were obviously improved than before treatment(P<0.05).Comparison between traditional Chinese medicine,western medicine group,the defecation time interval,chest,a new full,belching,early enough,five modern depression symptoms improve the situation,the Chinese traditional medicine than western medicine group obviously(P<0.05),but the nature of the waste,laborious,defecation time defecate,abdominal distension four symptoms differences between traditional Chinese medicine and western medicine group therapy effect is quite(P>0.05).See from the results,the curative effect of traditional Chinese medicine group better than western medicine group.So for the treatment of chronic functional constipation,there are more features and advantages of Chinese medicine.2.Experimental results:(1)the first grain of defecation time in mice to observe intestinal peristalsis of mice.The results showed that high dose group,middle dose group,low dose group,normal group,moser will fill the stomach after compared with model group,than first grain of black and discharge time of the model group(P<0.01).Compared with normal group and high dose group,no statistical significance(P>0.05),indicates that the high dose group can intestinal peristalsis of mice to restore normal function.Dose,low dose group compared with normal group,a statistically significant(P<0.05),suggesting the dose group and low dose group of high dose group is better than mice intestine peristalsis to improve the situation.And moser will be compared with the normal group,the group was statistically significant(P<0.05),and its improvement compared with dose group effect.In conclusion can be draw wood Que four gentleman decoction in the treatment of constipation,a dose dependent,and sufficient dose of Chinese traditional medicine than western medicine group effectively.(2)the first day of the model group,three days,five days,respectively,compared with normal group,black grain number decreased significantly,with statistical significance(P<0.001).Wood Que four jun tang high,medium and low dose in 3-5 days compared with model group,were statistically significant(P<0.01),(P<0.05).And high dose group compared with model group in the first days with statistical significance(P<0.05).Moser will group and low dose group in mice,the black out grain number.In conclusion can be draw the dosage in mice have influence on the grain number discharge,and sufficient dose of Chinese traditional medicine than western medicine group effectively.(3)the first day of the model group,three days,five days,respectively,compared with normal group,significantly reduce weight of excrement and urine,statistically significant(P<0.01).Wood Que four jun tang high,medium and low dose group,moser will in 1,3,5 days compared with model group,were statistically significant(P<0.01).The high,medium and low dose and moser will benefit group compared with normal group,in the first day was statistically significant(P<0.05),no obvious difference in 3,5 days,no statistical significance(P>0.05).Moser will group and wood Que four jun tang,the different dose groups,the difference was statistically significant(P<0.05).Above all,wood Que soup and four king moser will discharge waste weight has the effect in mice,but soup is better than wood Que four king moser will benefit.(4)by observing the mice not defecate number shows:in addition to normal mice without not defecate,after building the other group were not defecate have different Numbers of mice.Wood Que soup high,medium and low dose and four king moser will benefit group compared with model group,had statistical significance(P<0.05).Can be seen from the table below,wood Que four jun soup each dose not defecate mice quantity is less,and high dose of obvious,and is superior to the sand mo will benefit groups.In conclusion wood Que four gentleman decoction high dose group of qi deficiency,and qi)and constipation mice intestinal peristalsis improved obviously,black grain number and weight increase,not animals defecate number decreases.Traditional Chinese medicine group is better than western medicine group.Conclusion"Chaishao Sijun Jiawei Decoction" in the treatment of functional constipation curative effect significantly,especially for " Qixu and Qizhi type " constipation.To animal constipation model also has a significant effect,promote the bowel movement.The party is mainly in radix Chai Hu 10 g,Bai Shao 10 g,Dang Sheng 15 g,Fu Ling 15 g,Bai Zhu 15 g,Zhi Shi 10 g,Hou Po 10 g,Gan Cao6 g.