Review On Discussion And Treatment From Phlegm With MCI And In The Use Of Educational Research Yizhi Wendantang

OBJECTIVEIn order to find out the rule of differentiation and treatment of MCI，weinvestigated the clinical experience of tutor and aided Based on data miningtechnology and modern epidemiology statistical methods. In addition，with theherbal formula extracting from the Data Mining of the research，a clinicalresearch was performed in MCI patients， aiming at supporting theeffectiveness and safety of the treatment of MCI with Chinese TraditionalMedicine.METHODWe Collect the clinical MCI cases of tutor in recent years，First of all，theinformation of the clinical cases that met the inclusion criteria should to besaved. then the information is preprocessed and database was established withExcel software. By the use of statistical methods such as frequency analysiswas applied to find the commonly used medicines，symptom frequency，Differentiation type frequency， Prescription frequency and Thepharmacologic properties of frequency；Association rules was applied tosummarize the law of Clinical drug law of the tutor and the Close relationshipDrug combinations that treated the MCI were learned from clustering.A clinical research is performed with the herbal formula extracting from the Data Mining of the research，96patients with MCI were dividedinto treatment group and control group，the treatment group received YizhiWendantang； control group was given Donepezil.12weeks for a course.observing of the clinical efficacy (MMSE、DSR、ADL)，lipids (TG，H-LDLand L-LDL)，Aβ (Aβ1-40，Aβ1-42) and inflammatory factors (IL-1β，IL-6andTNF-α) and adverse reactions of Western medicine.RESULT1.Data mining results:（1）Symptom frequency analysis: cognitive dysfunction in the elderlycomplained of clinical symptoms in addition to " forgetfulness " other than themost frequent symptom is " Insomnia"，reached76.74%，the frequency ofother symptoms in more than20%in the order of: Burnout fatigue，dizziness，tinnitus，dizziness and heavy，chills，Nocturia，looking Shaohua，waistand knees，less gas lazy words，body fat，pale lips，poor appetite，nocturiaclear long，slow movement，bad breath，face limb edema，constipation，depression，phlegm，numbness，body weight difficulties，threateningswelling，dry mouth and throat，loose stool，mouth pain，abdominalswelling； common position elements in the kidney (70.43[difference apercent sign]%)，heart (59.47%) mainly，disease resistance elements aremainly phlegm (56.81%)，qi (52.49%) and blood stasis syndrome(36.54%).（2）Drug frequency analysis: The collected117cases diagnosed301times prescription frequency analysis，the total frequency of6，469times，come to the core of the drug were: Pinellia，Poria，Zhuru，foxglove，Atractylodes，Astragalus，Polygonum，Eucommia，Shichangpu，treatingdiabetes，Semen，Angelica，Albizia，white peony root，dogwood root，Chinese yam，Alisma，Anemarrhena，Divine Comedy，Bupleurum， Citrus，cohosh，a total of [number to the number only23，and later a poorlicorice]23flavor，use frequency were more than90times；Core drugs areclassified，the main drug class has tonic medicine，phlegm drugs and sedativedrug categories. Tonic medicine which is1759times the frequency of drug，frequency of46.52%，followed by phlegm drugs，and sedative drugs，frequency of13.54%and7.14%respectively. Four gas in accordance withdrugs，flavors，owned by the frequency of the use of more than5%of the67herbs for statistical analysis，the temperature of the drugs most frequentlyused，accounting for39.52%，followed by cold medicine and levelingagents，the frequency is32.73%，respectively，，22.15%.Potency analysisshowed the potency of the treatment were mainly used MCI sweet taste，bitter and pungent，the frequency is40.50%，25.50%and17.95%，respectively. The analysis showed that the treatment of MCI owned by multi-choice drugs Foot Jue Yin Liver Meridian，full moon spleen，hand Shao YinHeart Sutra，kidney meridian four meridians，the total frequency of64.14%.（3）Cluster analysis: the use of a frequency of more than5%of the67herbs clustering analysis，the treatment of MCI multi-drug combinationsflavor and body6to10commonly used drugs，including B2，B3，B6is atonic for； B1，B5is phlegm drugs on； B8is the blood of the drug； B7is antipyretic for； B9is uneasiness of mind on drugs； B4is yin drugson； B10is relieving drugs on， they are reflected from differentperspectives clinical tutor group Fang Siwei feature set of square principles.（4）association rules analysis: according to symptoms with prescriptionassociation rules analysis， the following results: the forgetfulness，insomnia，dizziness，moss greasy main symptoms，with the addition andsubtraction Yizhi Wendantang treatment； when insomnia，forgetfulness，pulse-based disease，often to Suanzaorentang； when fatigue，less gas lazy words based disease，commonly Buzhongyiqitang； in waist and knees，dizziness，tinnitus based disease when，like to use Liuweidihuang soup；utilize Erchen dampness and phlegm when body weight difficulties，phlegm，slippery pulse-based disease；With palpitations，spontaneous，white fur when I Yupingfengsan Qi solid form. According to the symptomswith medicine， Chinese medicine with symptom association rules，forgetfulness multi Breit， Zhuru， Shichangpu， treating diabetes，Polygonum； insomnia commonly Zaoren， Bozi， Poria， Zhuru，Shichangpu， Acacia leather， gutta； lassitude commonly used byastragalus，Chinese yam，Bupleurum，Cimicifuga； dizziness，tinnitus andmore with Rehmannia，white peony root，dogwood； dizziness and severemulti Breit，Shichangpu，Alisma； chills are often subject to Eucommia，treating diabetes，yam，dogwood； nocturia were more with gutta，dogwood，treating diabetes，yams；Looking Shaohua advised to chooseastragalus，angelica，white peony root，dogwood； Yaoxisuanruan multiRehmannia，Chinese yam，dogwood，Polygonum，treating diabetes；less gas lazy speaker election Astragalus，Atractylodes，yam，Bupleurum，Cimicifuga，Citrus； poor appetite suitably Astragalus，Atractylodes，Shichangpu，yams，Divine Comedy，Bupleurum，Citrus； surface limbedema plus Poria，Atractylodes，Astragalus，Alisma；depression advisedAlbizia，white peony root，angelica，Chuanxiong，Radix，Citrus；numbness plus Chuanxiong，Angelica；Threat of inflation by using Albizia，white peony root，Bupleurum；abdominal swelling by using Divine Comedy，Citrus，Pinellia，Zhuru palpitations with Poria，Radix，Polygonum，Semen.In short，the instructor of clinical medicine peace，not only to avoid defeatbitter Big Chill injured spleen stomach，and avoid injury Jin Xin consumptionof hot liquid，the clinical effectiveness of services to Yes.2.Clinical study results: （1）Comparison of efficacy of cognitive function:MCI patientscomprehensive cognitive ability，the ability to place orientation，timeorientation capabilities，immediate memory capacity，computing power，short-term memory capacity and language comprehension were significantlylower than the normal group. The treatment group and the control groupshowed no significant difference (P>0.05) in front of the indicators； Aftertreatment of cognitive ability，directional capabilities，immediate memorycapacity，computing power，short-term memory capacity has improvedsignificantly (P <0.05，P <0.01)；The control group before and after treatmentof cognitive ability，immediate memory capacity，computing power，short-term memory and language comprehension ability can compare theindicators have improved significantly (P <0.05，P <0.01)； compare the twogroups，the treatment group targeting capabilities improvement than thecontrol group (P <0.05)，language understanding can improve the controlgroup than the treatment group (P <0.05).（2）Memory level (DSR) compare the efficacy: treatment group andcontrol group DSR scores before and after treatment showed significantlyimproved (P <0.01) after treatment before DSR score than the treatmentgroup； former DSR score in the control group were significantly improvedcompared to treatment There was no statistical difference between the twogroups(P>0.05). Tip Yizhi Wendantang treatment of elderly patients with mildcognitive impairment，the two groups of patients before treatment than DSRintegration significantly improved (P <0.05)； with donepezil send its efficacywas no difference in the control group (P>0.05).（3）Comparison of activities of daily living: the treatment group and thecontrol group before and after treatment ADL comparison， significantimprovement in ADL scores than before treatment after treatment (P <0.01)，after treatment ADL scores than the control group before treatment improved significantly (P <0.01). The treatment group compared with the control groupsignificantly improved ADL，statistical analysis was no difference (P>0.05).Tip Yizhi Wendantang treatment of elderly patients with mild cognitiveimpairment after two groups of patients ADL points than before treatmentsignificantly improved； donepezil send compare the efficacy and nodifferences (P>0.05) in control groups.（4）Compare syndromes: syndrome score before and after treatmentshowed no significant difference； before and after treatment，spleen andkidney deficiency， blood deficiency， phlegm Mongolia awakened，hyperactivity symptom scores compared with four card before treatmentreduced (P <0.05)，each syndrome symptoms improved compared with beforetreatment，including spleen and kidney deficiency，blood deficiency andphlegm syndrome improve Mongolia awakened three most significant (P<0.01)；Each treatment group before and after treatment were not improvedsymptom scores (P>0.05)； symptom scores after treatment comparisonshowed that the treatment group spleen deficiency，lack of blood and phlegmMongolia awakened three syndromes compared with the control group asignificant improvement (P <0.01)， there is a certain improvement inhyperactivity syndrome (P <0.05). Yizhi Wendantang treatment of elderlypatients with mild cognitive impairment after，syndromes than the controlgroup.（5）Lipid levels were compared before and after treatment: the threegroups before treatment lipids compared with the treatment group and thecontrol group compared with cognitively normal HDL-C were lower (P<0.05)，TG and LDL-C showed no statistical difference. Treatment groupsignificantly increased HDL-C compared with pre-treatment (P <0.01)，compared with pre-treatment also decreased TG (P <0.05)； the control groupbefore and after treatment，compared with pre-treatment HDL-C increased (P <0.05)，TG and no significant difference in LDL-C after treatment. Aftertreatment，the treatment group compared with the control group HDL-Cincreased significantly (P <0.05)，TG and LDL-C was no significant difference(P>0.05).（6）Compared with the normal group，before treatment significantlyincreased plasma concentrations of Aβ1-42treatment group and the controlgroup (P <0.01)，while plasma concentrations of Aβ1-40and Aβ1-42: serumAβ1-40， Aβ1-42for comparison before and after treatment Aβ1-40/42comparison，there was no significant difference (P>0.05). After treatmentthan before treatment plasma concentrations of Aβ1-42is reduced，and thereis a significant difference (P <0.01)；after treatment than before treatmentcontrol group comparison，a significant difference (P <0.05). Treatment groupand control group， Aβ1-42was no significant difference in plasmaconcentration decreased (P>0.05). Prompt treatment and control groups caneffectively reduce serum Aβ1-42levels，and no significant difference (P>0.05)effect.（7）Comparison of serum inflammatory factors before and aftertreatment: Compared with the normal group，the treatment group and thecontrol group before treatment serum IL-1β，IL-6，TNF-α concentrations weresignificantly elevated compared with normal group with a statisticallysignificant difference (P <0.01). Treatment group after treatment than beforetreatment IL-1β，IL-6，expressing TNF-α were reduced，and there was asignificant difference (P <0.01)； than before treatment IL-1β in the controlgroup，IL-6，TNF expression-α were significantly decreased，and there wassignificant difference (P <0.05). Treatment group and control group，to moreeffectively inhibit the expression of IL-1β (P <0.05)； but at a reducedexpression of IL-6，the effect is better than the control group (P <0.05)； theexpression of TNF-α，the no significant difference (P>0.05). CONCLUSION1.Data mining is a summary of the heritage of Chinese medicinepractitioners experience an effective way，instructors can be summarizedrefining and treatment of drug law rules. MCI syndrome treatment whenpatients with heart disease，spleen，kidney main clinical manifestations ofinsomnia，fatigue，dizziness，tinnitus，dizziness and heavy，chills，nocturiaand other symptoms.Disease resistance to positive imaginary oriented，realevil is standard. Positive imaginary to kidney essence deficiency mainly withphlegm actually evil infestation. The use of frequency analysis，we havetonic， expectorant and sedative is MCI ’s main treatment method；association rules can be summed up drug compatibility rule of MCI； usingcluster analysis can be drawn from the treatment of MCI ’s commonly useddrugs combination.Analysis using data mining techniques massive Chinesemedical information to help find and laws associated with TCM therapy，prescription medication and other aspects implied，help to promote thedevelopment and innovation of traditional Chinese medicine.2.Yizhi Wendantang older MCI patients in improving the efficacy ofTCM symptoms and improve HDL-C levels，inhibit IL-1β expression interms of efficacy than donepezil send it； improve memory levels in patientswith activities of daily living，reduce Aβ1-42the plasma concentrations ofdonepezil sent his respects with similar efficacy. Therefore， YizhiWendantang MCI possible by reducing the potential neurotoxicity IL-1β，IL-6，TNF-α and other inflammatory cytokine secretion，reduced β amyloidprotein Aβ1-42’s， reducing nerve cells damage， thus delaying thedevelopment of MCI.