| Fatty liver is the pathological changes that means excessive triglyceride (TG) accumulates in the liver cells,.In clinical most patients do not have any obvious symptoms besides basic sickness and related performance,so it always diagnoses by by experimental&histopathological check, B ultrascan or CT.Westem medicine in lowering fat has damage on liver, so in contrary, Chinese medicine on the study of fatty liver pathogenesis and the treatment determination based on syndrome differentiaton has its superiority.This disease imputes to Liver, Spleen, Kidney,its formation related to phlegm, dampness, blockage and plot, so we proposed the Bu Shen Hua Tan Huo Xie method to treat fatty liver.Objective:According to traditional Chinese medicine theory and clinical experience, combined with modern medicine, to observe the clinical efficiency of Bu Shen Hua Tan Huo Xie method about treating Gan Yu Pi Xu,Gan Shen Kui Xu and Yu Xie Zu Luo non-alcoholic fatty livers, and combine with liver function test, kidney function test, lipid metabolism test, blood routine examination and B ultrasound scan, to explore the function and treatment effects.Methods:The research studies on80non-alcoholic fatty livers who are diagnosed as Gan-Yu-Pi-Xu, Gan-Shen-Kui-Xu and Yu-Xie-Zu-Luo types in Taiwan Dstrict,adopted random allocation principle,divided the qualified cases into two groups:one treatment group of40patients,another control group of40patients.and observe the efficiency of before and after treatment between the two groups. The composition of TCM herbs in treatment group are listed as below: sheng-huang-qi20g. dan-senl5g. chao-bai-zhulOg fu-linglOg huai-shan-yaolOg guang-yu-jinlOg chen-pi10g chwei-pen-cao10g chai-hu10g chi-shao10g ze-xie10g tu-si-zi10g sang-ji-sheng15g shan-zhu-yulOg shen-san-zha10g, boiled with water,one day one package,drink two times per day,and drink with san-qi powder1.5g every day.,one course for3months.The control group:taking RosuvastatinlOmg/d for3months.The observing indexes include:age,sex,weight,liver function,kidney function,lipid metabolism,blood routine examination,B ultrasound scan and clinical symptom score,the differences between two groups has no significant meaning(p>0.05),two groups have comparability.Result:1. The treatment group has40patients(basically cured13cases,19cases were obvious effective,3cases were effective,5cases were ineffective).The effective rate of treatment group is87.5%.The control group has40patients(basically cured7cases,10cases were obvious effective,9cases were effective,14cases were ineffective).the total effective rate of control group is65%,both of the two groups have significant differences(p<0.05). It means the effect of the treatment group for Pi Xu Tan Shi Yu Zu fatty livers is better than that of control group.2. Before and after treatment,from B ultrasound scan transformation comparison,both groups have obvious significant differences(p<0.01). The treatment group has19patients of fatty liver transform into normal type.The control group has12patients of fatty liver transform into normal type. Both of the two groups have the obvious improvement in B ultrasound scan.3.After treatment,both groups shows significant differences(p<0.05) in pathological changes of distension and pain in chest,in listlessness and lassitude,in sore and weakness of the waist and knees,in gloomy complexion,in chest tightness and palpitations,in tongue and sublingual blue veins.It means that the treatment group has the better effect than the control group in pathological changes of distension and pain in chest,in listlessness and lassitude,in sore and weakness of the waist and knees,in gloomy complexion,in chest tightness and palpitations,in tongue and sublingual blue veins.The symptom score average of the treatment group0.91>the control group0.64. The treatment group has better effect than the control group in poor appetite and digestion, in pathological changes of distension and pain in chest,in listlessness and lassitude,in sore and weakness of the waist and knees,in loose stools,in gloomy complexion,in sleep,in constipation induration, in chest tightness and palpitations,in frequent urination,,in tongue and sublingual blue veins.4.After treatment,both groups in liver function index (AST, ALT, ALP, r-GT) have significant differences(p<0.05). The treatment group of average between the differences of the liver function index (AST, ALT, ALP, r-GT)10.18> the control group5.41.The treatment group has better effect than the control group in liver function index (AST, ALT, ALP, r-GT).5. After treatment,both groups in lipid metabolism index (TC, TG, HDL-C, LDL-C)have significant differences (p<0.05). The treatment group has better effect than the control group in lipid metabolism index (TC, TG, HDL-C, LDL-C). The treatment group of average between the differences of the lipid metabolism index (TC, TG, HDL-C, LDL-C)1.20> the control group1.08.The treatment group has better effect than the control group in lipid metabolism index(TC, TG, HDL-C, LDL-C).6.After treatment, both groups in BUN have obvious significant differences(p<0.01).The treatment group has very best effect than the control group in BUN. After treatment, both groups in Creatinine have significant differences(p<0.05). The treatment group has better effect than the control group in Creatinine.The treatment group of average between the differences of the kindey function index3.43>the control group1.29.The treatment group has better effect than the control group in BUN,Creatinine. 7.After treatment, both groups in blood routine examination (WBC, RBC, PLT) have significant differences(p<0.05).The treatment group has better effect than the control group in blood routine examination index(WBC, RBC, PLT). The treatment group of average between the differences of the blood routine examination index (WBC, RBC, PLT)6.74>the control group1.93. The treatment group has better effect than the control group in blood routine examination index (WBC, RBC, PLT).Conclusion:The effect of treatment group in Gan-Yu-Pi-Xu,Gan-Shen-Kui-Xu and Yu-Xie-Zu-Luo non-alcohol fatty livers is better than that of control group.. |
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